The role of HPV-induced epigenetic changes in cervical carcinogenesis (Review).

Autor: Da Silva MLR; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.; Post-Graduate Program in Parasite Biology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil., De Albuquerque BHDR; Laboratory of Applied Molecular Biology, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil., Allyrio TAMF; Department of Biomedical Sciences, State University of Rio Grande do Norte, Mossoro 59607-360, Brazil., De Almeida VD; Department of Biomedical Sciences, State University of Rio Grande do Norte, Mossoro 59607-360, Brazil., Cobucci RNO; Department of Gynecology and Obstetrics, Potiguar University, Natal 59056-000, Brazil., Bezerra FL; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil., Andrade VS; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.; Post-Graduate Program in Parasite Biology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil., Lanza DCF; Laboratory of Applied Molecular Biology, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil., De Azevedo JCV; Department of Pediatrics, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., De Araújo JMG; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.; Post-Graduate Program in Parasite Biology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil., Fernandes JV; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.; Post-Graduate Program in Parasite Biology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.
Jazyk: angličtina
Zdroj: Biomedical reports [Biomed Rep] 2021 Jul; Vol. 15 (1), pp. 60. Date of Electronic Publication: 2021 May 20.
DOI: 10.3892/br.2021.1436
Abstrakt: Cervical cancer is associated with infection by certain types of human papillomaviruses (HPVs), and this affects women worldwide. Despite the improvements in prevention and cure of HPV-induced cervical cancer, it remains the second most common type of cancer in women in the least developed regions of the world. Epigenetic modifications are stable long-term changes that occur in the DNA, and are part of a natural evolutionary process of necessary adaptations to the environment. They do not result in changes in the DNA sequence, but do affect gene expression and genomic stability. Epigenetic changes are important in several biological processes. The effects of the environment on gene expression can contribute to the development of numerous diseases. Epigenetic modifications may serve a critical role in cancer cells, by silencing tumor suppressor genes, activating oncogenes, and exacerbating defects in DNA repair mechanisms. Although cervical cancer is directly related to a persistent high-risk HPV infection, several epigenetic changes have been identified in both the viral DNA and the genome of the infected cells: DNA methylation, histone modification and gene silencing by non-coding RNAs, which initiate and sustain epigenetic changes. In the present review, recent advances in the role of epigenetic changes in cervical cancer are summarized.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © Da Silva et al.)
Databáze: MEDLINE
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