Et 3 SiH + KO t Bu provide multiple reactive intermediates that compete in the reactions and rearrangements of benzylnitriles and indolenines.

Autor:	Smith AJ; Department of Pure and Applied Chemistry Thomas Graham Building, 295 Cathedral Street Glasgow G1 1XL UK john.murphy@strath.ac.uk., Dimitrova D; Department of Pure and Applied Chemistry Thomas Graham Building, 295 Cathedral Street Glasgow G1 1XL UK john.murphy@strath.ac.uk., Arokianathar JN; Department of Pure and Applied Chemistry Thomas Graham Building, 295 Cathedral Street Glasgow G1 1XL UK john.murphy@strath.ac.uk., Clark KF; Department of Pure and Applied Chemistry Thomas Graham Building, 295 Cathedral Street Glasgow G1 1XL UK john.murphy@strath.ac.uk., Poole DL; GlaxoSmithKline Medicines Research Centre Gunnels Wood Road Stevenage Hertfordshire SG1 2NY UK., Leach SG; GlaxoSmithKline Medicines Research Centre Gunnels Wood Road Stevenage Hertfordshire SG1 2NY UK., Murphy JA; Department of Pure and Applied Chemistry Thomas Graham Building, 295 Cathedral Street Glasgow G1 1XL UK john.murphy@strath.ac.uk.
Jazyk:	angličtina
Zdroj:	Chemical science [Chem Sci] 2020 Oct 21; Vol. 11 (45), pp. 12364-12370. Date of Electronic Publication: 2020 Oct 21.
DOI:	10.1039/d0sc04244g
Abstrakt:	The combination of potassium tert -butoxide and triethylsilane is unusual because it generates multiple different types of reactive intermediates simultaneously that provide access to (i) silyl radical reactions, (ii) hydrogen atom transfer reactions to closed shell molecules and to radicals, (iii) electron transfer reductions and (iv) hydride ion chemistry, giving scope for unprecedented outcomes. Until now, reactions with this reagent pair have generally been explained by reference to one of the intermediates, but we now highlight the interplay and competition between them. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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