Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria.
| Autor: | Matshwele JTP; Botswana International University of Science and Technology, Department of Chemistry and Forensic Sciences, Private Bag 16, Palapye, Botswana.; Botho University, Department of Applied Sciences, PO Box, Gaborone 501564, Botswana., Odisitse S; Botswana International University of Science and Technology, Department of Chemistry and Forensic Sciences, Private Bag 16, Palapye, Botswana., Mapolelo D; University of Botswana, Faculty of Science, Private Bag, Gaborone 0704, Botswana., Leteane M; University of Botswana, Faculty of Science, Private Bag, Gaborone 0704, Botswana., Julius LG; University of Botswana, Faculty of Science, Private Bag, Gaborone 0704, Botswana., Nkwe DO; Botswana International University of Science and Technology, Department of Biological Sciences and Biotechnology, Private Bag 16, Palapye, Botswana., Nareetsile F; University of Botswana, Faculty of Science, Private Bag, Gaborone 0704, Botswana. |
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| Jazyk: | angličtina |
| Zdroj: | Bioinorganic chemistry and applications [Bioinorg Chem Appl] 2021 May 20; Vol. 2021, pp. 5563209. Date of Electronic Publication: 2021 May 20 (Print Publication: 2021). |
| DOI: | 10.1155/2021/5563209 |
| Abstrakt: | A new hexadentate 2-picolyl-polypyridyl-based ligand (4, 4'-(butane-1, 4-diylbis(oxy))bis(N, N-bis(pyridin-2-ylmethyl)aniline)) (2BUT) (1) and its corresponding Ru(II/III) complexes were synthesized and characterized, followed by assessment of their possible bioactive properties towards drug-resistant and non-drug-resistant bacteria. Spectroscopic characterization of the ligand was done using proton NMR, FTIR, and ESI-MS, which showed that the ligand was successfully synthesized. The Ru(II/III) complexes were characterized by FTIR, UV/Vis, elemental analysis, proton NMR, ESI-MS, and magnetic susceptibility studies. The analysis of ESI-MS data of the complexes showed that they were successfully synthesized. Empirical formulae derived from elemental analysis of the complexes also indicated successful synthesis and relative purity of the complexes. The important functional groups of the ligands could be observed after complexation using FTIR. Magnetic susceptibility data and electronic spectra indicated that both complexes adopt a low spin configuration. The disc diffusion assay was used to test the compounds for antibiotic activity on two bacteria species and their drug-resistant counterparts. The compounds displayed antibiotic activity towards the two non-drug-resistant bacteria. As for the drug-resistant organisms, only [Ru Competing Interests: The authors declare that they have no conflicts of interest. (Copyright © 2021 James T. P. Matshwele et al.) |
| Databáze: | MEDLINE |
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