Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise.

Autor: Smith JR; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address: smith.joshua1@mayo.edu., Hirai DM; Department of Health and Kinesiology, Purdue University, West Lafayette, IN, United States., Copp SW; Department of Kinesiology, Kansas State University, Manhattan, KS, United States., Ferguson SK; Department of Kinesiology and Exercise Sciences, University of Hawaii, Hilo, HI, United States., Holdsworth CT; Department of Kinesiology, Kansas State University, Manhattan, KS, United States; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, United States., Hageman KS; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, United States., Poole DC; Department of Kinesiology, Kansas State University, Manhattan, KS, United States; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, United States., Musch TI; Department of Kinesiology, Kansas State University, Manhattan, KS, United States; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, United States.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2021 Oct; Vol. 292, pp. 103710. Date of Electronic Publication: 2021 Jun 04.
DOI: 10.1016/j.resp.2021.103710
Abstrakt: Diaphragm muscle blood flow (BF) and vascular conductance (VC) are elevated with chronic heart failure (HF) during exercise. Exercise training (ExT) elicits beneficial respiratory muscle and pulmonary system adaptations in HF. We hypothesized that diaphragm BF and VC would be lower in HF rats following ExT than their sedentary counterparts (Sed). Respiratory muscle BFs and mean arterial pressure were measured via radiolabeled microspheres and carotid artery catheter, respectively, during submaximal treadmill exercise (20 m/min, 5 % grade). During exercise, no differences were present between HF + ExT and HF + Sed in diaphragm BFs (201 ± 36 vs. 227 ± 44 mL/min/100 g) or VCs (both, p > 0.05). HF + ExT compared to HF + Sed had lower intercostal BF (27 ± 3 vs. 41 ± 5 mL/min/100 g) and VC (0.21 ± 0.02 vs. 0.31 ± 0.04 mL/min/mmHg/100 g) during exercise (both, p < 0.05). Further, HF + ExT compared to HF + Sed had lower transversus abdominis BF (20 ± 1 vs. 35 ± 6 mL/min/100 g) and VC (0.14 ± 0.02 vs. 0.27 ± 0.05 mL/min/mmHg/100 g) during exercise (both, p < 0.05). These data suggest that exercise training lowers the intercostal and transversus abdominis BF responses in HF rats during submaximal treadmill exercise.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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