Neonatal Cranial Ultrasound Findings among Infants Born Extremely Preterm: Associations with Neurodevelopmental Outcomes at 10 Years of Age.

Autor: Campbell H; Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC., Check J; Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC., Kuban KCK; Department of Pediatrics, Division of Pediatric Neurology, Boston University Medical Center, Boston, MA., Leviton A; Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA., Joseph RM; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA., Frazier JA; Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Worcester, MA., Douglass LM; Department of Pediatrics, Division of Pediatric Neurology, Boston University Medical Center, Boston, MA., Roell K; Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC., Allred EN; Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA., Fordham LA; Department of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC., Hooper SR; Department of Allied Health, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC., Jara H; Department of Radiology, Boston University Medical Center, Boston, MA., Paneth N; Michigan State University College of Human Medicine, East Lansing, MI., Mokrova I; Duke University School of Medicine, Durham, NC., Ru H; Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC., Santos HP Jr; Biobehavioral Laboratory, School of Nursing, University of North Carolina, Chapel Hill, NC., Fry RC; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC., O'Shea TM; Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC. Electronic address: moshea52@email.unc.edu.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2021 Oct; Vol. 237, pp. 197-205.e4. Date of Electronic Publication: 2021 Jun 04.
DOI: 10.1016/j.jpeds.2021.05.059
Abstrakt: Objective: To examine the association between neonatal cranial ultrasound (CUS) abnormalities among infants born extremely preterm and neurodevelopmental outcomes at 10 years of age.
Study Design: In a multicenter birth cohort of infants born at <28 weeks of gestation, 889 of 1198 survivors were evaluated for neurologic, cognitive, and behavioral outcomes at 10 years of age. Sonographic markers of white matter damage (WMD) included echolucencies in the brain parenchyma and moderate to severe ventricular enlargement. Neonatal CUS findings were classified as intraventricular hemorrhage (IVH) without WMD, IVH with WMD, WMD without IVH, and neither IVH nor WMD.
Results: WMD without IVH was associated with an increased risk of cognitive impairment (OR 3.5, 95% CI 1.7, 7.4), cerebral palsy (OR 14.3, 95% CI 6.5, 31.5), and epilepsy (OR 6.9; 95% CI 2.9, 16.8). Similar associations were found for WMD accompanied by IVH. Isolated IVH was not significantly associated these outcomes.
Conclusions: Among children born extremely preterm, CUS abnormalities, particularly those indicative of WMD, are predictive of neurodevelopmental impairments at 10 years of age. The strongest associations were found with cerebral palsy.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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