Snake venom vascular endothelial growth factors (svVEGFs): Unravelling their molecular structure, functions, and research potential.

Autor: Ferreira IG; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Pucca MB; Medical School, Federal University of Roraima, Boa Vista, RR, Brazil., Oliveira IS; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Cerni FA; Health Sciences Postgraduate Program, Federal University of Roraima, Boa Vista, RR, Brazil., Jacob BCDS; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Arantes EC; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: ecabraga@fcfrp.usp.br.
Jazyk: angličtina
Zdroj: Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2021 Aug; Vol. 60, pp. 133-143. Date of Electronic Publication: 2021 May 28.
DOI: 10.1016/j.cytogfr.2021.05.003
Abstrakt: Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, a physiological process characterized by the formation of new vessels from a preexisting endothelium. VEGF has also been implicated in pathologic states, such as neoplasias, intraocular neovascular disorders, among other conditions. VEGFs are distributed in seven different families: VEGF-A, B, C, D, and PIGF (placental growth factor), which are identified in mammals; VEGF-E, which are encountered in viruses; and VEGF-F or svVEGF (snake venom VEGF) described in snake venoms. This is the pioneer review of svVEGF family, exploring its distribution among the snake venoms, molecular structure, main functions, and potential applications.
(Copyright © 2021. Published by Elsevier Ltd.)
Databáze: MEDLINE
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