Differential neural structures, intrinsic functional connectivity, and episodic memory in subjective cognitive decline and healthy controls.

Autor: Nellessen N; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany; Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; Department of Neurology and Clinical Neurophysiology, Helios University Hospital Wuppertal, 42283 Wuppertal, Germany; Faculty of Health, Witten/Herdecke University, Witten, Germany., Onur OA; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany; Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. Electronic address: o.onur@fz-juelich.de., Richter N; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany; Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Jacobs HIL; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg; Maastricht University, Maastricht, Netherlands; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Dillen KNH; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany., Reutern BV; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany; Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Langen KJ; Institute of Neuroscience and Medicine (INM-4), Research Center Jülich, Jülich, Germany; Department of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany., Fink GR; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany; Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Kukolja J; Department of Neurology and Clinical Neurophysiology, Helios University Hospital Wuppertal, 42283 Wuppertal, Germany; Faculty of Health, Witten/Herdecke University, Witten, Germany.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2021 Sep; Vol. 105, pp. 159-173. Date of Electronic Publication: 2021 Apr 28.
DOI: 10.1016/j.neurobiolaging.2021.04.016
Abstrakt: The neural correlates of subjective cognitive decline (SCD; i.e., without objectifiable deficit) remain to be elucidated. Possible causes of SCD include early neurodegeneration related to Alzheimer's disease or functional and structural changes related to sub-clinical depression. We investigated the relationship between episodic memory performance or memory complaints and structural or functional magnetic resonance imaging (MRI) measures in participants with SCD (n=18) but without psychiatric disorders and healthy controls (n=31). In SCD, memory complaints were not associated with memory performance but with sub-clinical depression and executive functions. SCD-associated memory complaints correlated with higher amygdala and parahippocampal gyrus (specifically subiculum) gray matter density. In controls, but not in SCD, mesiotemporal gray matter density and superior frontal gyrus functional connectivity predicted memory performance. In contrast, in SCD, only a trend toward a correlation between memory performance and gray matter density in the parietooccipital lobes was observed. In our memory-clinic sample of SCD, we did not observe incipient neurodegeneration (limited to structural and functional MRI) but rather sub-clinical depression underlying subjective cognitive complaints.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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