An overview of adapalene and benzoyl peroxide once-daily topical gel as a therapeutic option for acne.

Autor:	Emmerich VK; Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina., Purvis CG; Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina., Feldman SR; Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.; Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston- Salem, North Carolina.; Department of Dermatology, University of Southern Denmark, Odense, Denmark.
Jazyk:	angličtina
Zdroj:	Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2021 Sep; Vol. 22 (13), pp. 1661-1667. Date of Electronic Publication: 2021 Jun 14.
DOI:	10.1080/14656566.2021.1939678
Abstrakt:	Introduction: Acne vulgaris is the most common skin condition worldwide, and it is associated with substantial psychological comorbidity. Topical therapies - including retinoids, antibiotics, and benzoyl peroxide - are the cornerstones of treatment for patients with acne. The main barriers to care in the treatment of acne are poor adherence to therapy and lack of tolerability. Areas Covered: Herein, the authors review the safety and efficacy of adapalene/benzoyl peroxide combination gel (0.1%/2.5% and 0.3%/2.5%), as well as its specific mechanisms of action that target acne vulgaris. The authors also offer an expert opinion on the use of adapalene/benzoyl peroxide gel compared with other topical therapies. Expert Opinion: Adapalene/benzoyl peroxide gel is safe and highly effective in the treatment of acne vulgaris. Its efficacy, tolerability, and ease-of-use are superior to other topical acne therapies, and its use does not contribute to antibiotic resistance. However, the cost of adapalene/benzoyl peroxide gel and lack of available generics may prohibit its use.
Databáze:	MEDLINE
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