Effectiveness of an herbaceous derivatives, PHGG, plus sodium hyaluronate in the treatment of chronic constipation in patients with Parkinson's disease: a pilot study.

Autor: Vacca L; Institute for Research and Medical Care, San Raffaele Roma Italy, Via della Pisana 235, 00163, Rome, Italy., Proietti S; Institute for Research and Medical Care, San Raffaele Roma Italy, Via della Pisana 235, 00163, Rome, Italy., Bravi D; Institute for Research and Medical Care, San Raffaele Roma Italy, Via della Pisana 235, 00163, Rome, Italy., Radicati FG; Institute for Research and Medical Care, San Raffaele Roma Italy, Via della Pisana 235, 00163, Rome, Italy., Stocchi F; University and Institute for Research and Medical Care San Raffaele Roma Italy, Via della Pisana 235, 00163, Roma, Italy. fabrizio.stocchi@uniroma5.it.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2022 Feb; Vol. 43 (2), pp. 1055-1059. Date of Electronic Publication: 2021 Jun 04.
DOI: 10.1007/s10072-021-05342-8
Abstrakt: Chronic constipation is a highly prevalent and often under-appreciated gastrointestinal disorder in PD associated with significant impairment in quality of life. In this study, we investigated the efficacy and safety of PHGG plus hyaluronate (PHGG+) in patients suffering from PD and constipation. Thirty-four PD patients have been recruited in an open-label pilot study and measured symptoms and quality of life instruments related to constipation. PHGG+ showed to have a minimal still significant effect in improving constipation as measured by PAC Symp and CGI-S. PHGG+ is safe and well tolerated. Data suggests that PHGG+ may be considered efficacious in alleviating symptoms of constipation in PD patients. Trial registration number: NCT04569656/24 Sept. 2020.
(© 2021. Fondazione Società Italiana di Neurologia.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje