One-year infection control rates of a DAIR (debridement, antibiotics and implant retention) procedure after primary and prosthetic-joint-infection-related revision arthroplasty - a retrospective cohort study.

Autor:	Nurmohamed FRHA; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands., van Dijk B; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands., Veltman ES; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands., Hoekstra M; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands., Rentenaar RJ; Department of Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Weinans HH; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of BioMechanical Engineering, Delft University of Technology, Delft, the Netherlands., Vogely HC; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands., van der Wal BCH; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of bone and joint infection [J Bone Jt Infect] 2021 Jan 27; Vol. 6 (4), pp. 91-97. Date of Electronic Publication: 2021 Jan 27 (Print Publication: 2021).
DOI:	10.5194/jbji-6-91-2021
Abstrakt:	Introduction : Debridement, antibiotics and implant retention (DAIR) procedures are effective treatments for acute postoperative or acute hematogenous periprosthetic joint infections. However, literature reporting on the effectiveness of DAIR procedures performed after a one- or two-stage revision because of a prosthetic joint infection (PJI) (PJI-related revision arthroplasty) is scarce. The aim of this study is to retrospectively evaluate the infection control after 1 year of a DAIR procedure in the case of an early postoperative infection either after primary arthroplasty or after PJI-related revision arthroplasty. Materials and methods : All patients treated with a DAIR procedure within 3 months after onset of PJI between 2009 and 2017 were retrospectively included. Data were collected on patient and infection characteristics. All infections were confirmed by applying the Musculoskeletal Infection Society (MSIS) 2014 criteria. The primary outcome was successful control of infection at 1 year after a DAIR procedure, which was defined as the absence of clinical signs, such as pain, swelling, and erythema; radiological signs, such as protheses loosening; or laboratory signs, such as C-reactive protein (CRP) ( < 10 ) with no use of antibiotic therapy. Results : Sixty-seven patients were treated with a DAIR procedure (41 hips and 26 knees). Successful infection control rates of a DAIR procedure after primary arthroplasty ( n = 51 ) and after prior PJI-related revision arthroplasty ( n = 16 ) were 69 % and 56 %, respectively ( p = 0.38 ). The successful infection control rates of a DAIR procedure after an early acute infection ( n = 35 ) and after a hematogenous infection ( n = 16 ) following primary arthroplasty were both 69 % ( p = 1.00 ). Conclusion : In this limited study population, no statistically significant difference is found in infection control after 1 year between DAIR procedures after primary arthroplasty and PJI-related revision arthroplasty. Competing Interests: The authors declare that they have no conflict of interest. (Copyright: © 2021 F. Ruben H. A. Nurmohamed et al.)
Databáze:	MEDLINE
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