Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro- and nanofibres doped with lithium.

Autor: Riveiro A; Materials Engineering, Applied Mechanics and Construction Dpt., University of Vigo, EEI, Lagoas-Marcosende, Vigo 36310, Spain. Electronic address: ariveiro@uvigo.es., Amorim S; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4805-017, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal., Solanki A; Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK., Costa DS; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4805-017, Portugal., Pires RA; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4805-017, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal., Quintero F; Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, Vigo 36310, Spain., Del Val J; Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, Vigo 36310, Spain., Comesaña R; Materials Engineering, Applied Mechanics and Construction Dpt., University of Vigo, EEI, Lagoas-Marcosende, Vigo 36310, Spain., Badaoui A; Materials Engineering, Applied Mechanics and Construction Dpt., University of Vigo, EEI, Lagoas-Marcosende, Vigo 36310, Spain., Lusquiños F; Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, Vigo 36310, Spain., Maçon ALB; Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK., Tallia F; Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK., Jones JR; Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK., Reis RL; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4805-017, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal., Pou J; Applied Physics Department, University of Vigo, EEI, Lagoas-Marcosende, Vigo 36310, Spain.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2021 Jul; Vol. 126, pp. 112124. Date of Electronic Publication: 2021 Apr 23.
DOI: 10.1016/j.msec.2021.112124
Abstrakt: The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mechanical and biological requirements for a successful outcome. Here, we reinforce hyaluronic acid (HA) hydrogels with 13-93-lithium bioactive glass micro- and nanofibres produced by laser spinning. The glass fibres are a reinforcement filler and a platform for the delivery of therapeutic lithium-ions. The elastic modulus of the composites is more than three times higher than in HA hydrogels. Modelling of the reinforcement corroborates the experimental results. ATDC5 chondrogenic cells seeded on the composites are viable and more proliferation occurs on the hydrogels containing fibres than in HA hydrogels alone. Furthermore, the chondrogenic behavior on HA constructs with fibres containing lithium is more marked than in hydrogels with no-lithium fibres.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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