Easier and more explanatory indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) to IPS systems in cases with classical Hodgkin lymphoma.

Autor: Paydas S; Cukurova University, Faculty of Medicine, Dept of Oncology, Turkey; Cukurova University, Faculty of Medicine, Dept of Hematology, Turkey. Electronic address: sepay@cu.edu.tr., Lacin S; Hacettepe University, Faculty of Medicine, Dept of Oncology, Turkey., Dogan M; Ankara Numune Hospital, Dept of Oncology, Turkey., Barista I; Hacettepe University, Faculty of Medicine, Dept of Oncology, Turkey., Yildiz B; Gulhane Hospital, Dept of Oncology, Turkey., Seydaoglu G; Cukurova University, Faculty of Medicine, Dept of Biostatistics, Turkey., Karadurmus N; Gulhane Hospital, Dept of Oncology, Turkey., Civriz S; Ankara University, Faculty of Medicine, Dept of Hematology, Turkey., Kaplan MA; Dicle University, Faculty of Medicine, Dept of Oncology, Turkey., Yagci M; Gazi University, Faculty of Medicine, Dept of Hematology, Turkey., Dincyurek HD; Cukurova University, Faculty of Medicine, Dept of Hematology, Turkey., Ercolak V; Cukurova University, Faculty of Medicine, Dept of Oncology, Turkey.
Jazyk: angličtina
Zdroj: Leukemia research [Leuk Res] 2021 Aug; Vol. 107, pp. 106586. Date of Electronic Publication: 2021 Apr 24.
DOI: 10.1016/j.leukres.2021.106586
Abstrakt: The aim of this study is to determine the power of he international prognostic scoring systems (IPS-7 and IPS-3) and to obtain indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) factors as prognostic indicators in cases with classical Hodgkin lymphoma (cHL). 1012 patients with cHL were evaluated with 2 different IPS-4 scores with four parameters: stage, age, hemoglobin level, and either LLR or PNI. Statistical package SPSS v 22.0 was used. Two different Cox regression models were obtained for OS and PFS. Model 1 showed LLR ≥ 5,8 as the highest risk for OS and anemia as the highest risk for PFS. Model 2 showed PNI ≤ 45,2 as the highest risk for OS and anemia as the highest risk for PFS. IPS-4 scores obtained by integrating either LLR or PNI to IPS-3 integration of a biologic parameter either LLR or PNI need to be determined with clinical risk scoring parameters.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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