Hydrogen sulfide donor protects against mechanical ventilation-induced atrophy and contractile dysfunction in the rat diaphragm.
Autor: | Ichinoseki-Sekine N; Graduate School of Arts and Sciences, The Open University of Japan, Chiba, Japan.; School of Health and Sports Science, Juntendo University, Inzai, Japan., Smuder AJ; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Morton AB; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Hinkley JM; AdventHealth Translational Research Institute, Orlando, Florida, USA., Mor Huertas A; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Powers SK; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA. |
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Jazyk: | angličtina |
Zdroj: | Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2139-2145. Date of Electronic Publication: 2021 Jun 16. |
DOI: | 10.1111/cts.13081 |
Abstrakt: | Mechanical ventilation (MV) is a clinical tool providing adequate alveolar ventilation in patients that require respiratory support. Although a life-saving intervention for critically ill patients, prolonged MV results in the rapid development of inspiratory muscle weakness due to both diaphragmatic atrophy and contractile dysfunction; collectively known as "ventilator-induced diaphragm dysfunction" (VIDD). VIDD is a severe clinical problem because diaphragmatic weakness is a risk factor for difficulties in weaning patients from MV. Currently, no standard treatment to prevent VIDD exists. Nonetheless, growing evidence reveals that hydrogen sulfide (H (© 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.) |
Databáze: | MEDLINE |
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