The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing.
| Autor: | Hertrich I; Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Dietrich S; Evolutionary Cognition, Department of Psychology, University of Tübingen, Tübingen, Germany., Blum C; Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Ackermann H; Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in human neuroscience [Front Hum Neurosci] 2021 May 17; Vol. 15, pp. 645209. Date of Electronic Publication: 2021 May 17 (Print Publication: 2021). |
| DOI: | 10.3389/fnhum.2021.645209 |
| Abstrakt: | This review article summarizes various functions of the dorsolateral prefrontal cortex (DLPFC) that are related to language processing. To this end, its connectivity with the left-dominant perisylvian language network was considered, as well as its interaction with other functional networks that, directly or indirectly, contribute to language processing. Language-related functions of the DLPFC comprise various aspects of pragmatic processing such as discourse management, integration of prosody, interpretation of nonliteral meanings, inference making, ambiguity resolution, and error repair. Neurophysiologically, the DLPFC seems to be a key region for implementing functional connectivity between the language network and other functional networks, including cortico-cortical as well as subcortical circuits. Considering clinical aspects, damage to the DLPFC causes psychiatric communication deficits rather than typical aphasic language syndromes. Although the number of well-controlled studies on DLPFC language functions is still limited, the DLPFC might be an important target region for the treatment of pragmatic language disorders. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Hertrich, Dietrich, Blum and Ackermann.) |
| Databáze: | MEDLINE |
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