In vitro Anticancer Effects of Vernonia amygdalina Leaf Extract and Green-Synthesised Silver Nanoparticles.
| Autor: | Joseph J; Integrative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Sains@BERTAM, Universiti Sains Malaysia, Kepala Batas, 13200, Pulau Pinang, Malaysia., Khor KZ; Integrative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Sains@BERTAM, Universiti Sains Malaysia, Kepala Batas, 13200, Pulau Pinang, Malaysia., Moses EJ; Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Sains@BERTAM, Universiti Sains Malaysia, Kepala Batas, 13200, Pulau Pinang, Malaysia., Lim V; Integrative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Sains@BERTAM, Universiti Sains Malaysia, Kepala Batas, 13200, Pulau Pinang, Malaysia., Aziz MY; Integrative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Sains@BERTAM, Universiti Sains Malaysia, Kepala Batas, 13200, Pulau Pinang, Malaysia., Abdul Samad N; Integrative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Sains@BERTAM, Universiti Sains Malaysia, Kepala Batas, 13200, Pulau Pinang, Malaysia. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of nanomedicine [Int J Nanomedicine] 2021 May 25; Vol. 16, pp. 3599-3612. Date of Electronic Publication: 2021 May 25 (Print Publication: 2021). |
| DOI: | 10.2147/IJN.S303921 |
| Abstrakt: | Purpose: Vernonia amygdalina (VA) is a traditional African herbal medicine that has been reported to possess anticancer properties. However, the anticancer properties of VA silver nanoparticles have not been studied. The aim of the study was to examine and evaluate the anticancer activities of VA leaf extracts and VA silver nanoparticles on the human breast cancer cell line, MCF-7. Methods: VA leaves were extracted using sequential extraction assisted with ultrasound using three different solvents: ethanol, 50% ethanol, and deionized water. The silver nanoparticles were synthesised with VA aqueous extract. Results: The ethanol extract and VA silver nanoparticles inhibit MCF-7 cell proliferation with an average half-maximal inhibitory concentration (IC Conclusion: VA ethanol extracts and VA silver nanoparticles decreased the cell viability in MCF-7 cells in a time and dose-dependent manner by inducing apoptosis and causing DNA damage. Further research is needed to elucidate the mechanism of action of VA leaf extracts and VA silver nanoparticles. This study is the first to report on the anticancer activity of VA silver nanoparticles in MCF-7 cells. Competing Interests: The authors declare no conflict of interest associated with this work. (© 2021 Joseph et al.) |
| Databáze: | MEDLINE |
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