Thalamic control of cortical dynamics in a model of flexible motor sequencing.

Autor:	Logiaco L; Zuckerman Institute, Department of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Institute, Department of Psychiatry, Columbia University, New York, NY 10027, USA. Electronic address: laureline.logiaco@gmail.com., Abbott LF; Zuckerman Institute, Department of Neuroscience, Columbia University, New York, NY 10027, USA., Escola S; Zuckerman Institute, Department of Psychiatry, Columbia University, New York, NY 10027, USA.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2021 Jun 01; Vol. 35 (9), pp. 109090.
DOI:	10.1016/j.celrep.2021.109090
Abstrakt:	The neural mechanisms that generate an extensible library of motor motifs and flexibly string them into arbitrary sequences are unclear. We developed a model in which inhibitory basal ganglia output neurons project to thalamic units that are themselves bidirectionally connected to a recurrent cortical network. We model the basal ganglia inhibitory patterns as silencing some thalamic neurons while leaving others disinhibited and free to interact with cortex during specific motifs. We show that a small number of disinhibited thalamic neurons can control cortical dynamics to generate specific motor output in a noise-robust way. Additionally, a single "preparatory" thalamocortical network can produce fast cortical dynamics that support rapid transitions between any pair of learned motifs. If the thalamic units associated with each sequence component are segregated, many motor outputs can be learned without interference and then combined in arbitrary orders for the flexible production of long and complex motor sequences. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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