Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis.

Autor: Bah GS; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Schneckener S; Bayer AG, Engineering & Technology, Applied Mathematics, Leverkusen, Germany., Hahnel SR; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Bayang NH; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Fieseler H; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Schmuck GM; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Krebber R; Bayer AG, Crop Science Division, Research & Development-Regulatory Science-Human Safety-Residue Analysis, Monheim am Rhein, Germany., Sarr A; INVENesis Sarl, St-Blaise (NE), Switzerland., Terjung C; Bayer AG, Pharmaceuticals, DMPK, Wuppertal, Germany., Ngangyung HF; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Ekale DD; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Mfopit YM; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Rufener L; INVENesis Sarl, St-Blaise (NE), Switzerland., Graham-Brown J; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Tanya VN; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun.; Cameroon Academy of Sciences, Yaoundé, Cameroon., Glenschek-Sieberth M; Bayer AG, Pharmaceuticals, Wuppertal, Germany., Kulke D; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Makepeace BL; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2021 Jun 02; Vol. 17 (6), pp. e1009601. Date of Electronic Publication: 2021 Jun 02 (Print Publication: 2021).
DOI: 10.1371/journal.ppat.1009601
Abstrakt: Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and is responsible for >1.3 million years lived with disability. Current control relies almost entirely on ivermectin, which suppresses symptoms caused by the first-stage larvae (microfilariae) but does not kill the long-lived adults. Here, we evaluated emodepside, a semi-synthetic cyclooctadepsipeptide registered for deworming applications in companion animals, for activity against adult filariae (i.e., as a macrofilaricide). We demonstrate the equivalence of emodepside activity on SLO-1 potassium channels in Onchocerca volvulus and Onchocerca ochengi, its sister species from cattle. Evaluation of emodepside in cattle as single or 7-day treatments at two doses (0.15 and 0.75 mg/kg) revealed rapid activity against microfilariae, prolonged suppression of female worm fecundity, and macrofilaricidal effects by 18 months post treatment. The drug was well tolerated, causing only transiently increased blood glucose. Female adult worms were mostly paralyzed; however, some retained metabolic activity even in the multiple high-dose group. These data support ongoing clinical development of emodepside to treat river blindness.
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: AS and LR received a contract research grant from Bayer Animal Health GmbH (to INVENesis). BLM received a contract research grant from Bayer Pharma AG (to the University of Liverpool) to conduct the work presented. SS, HF, SRH, GMS, RK, CT, MGS, and DK are employees of Bayer, or were employees of Bayer when the work was undertaken. MGS owns Bayer stocks. GSB, NHB, HFN, DDE, YMM, JGB and VNT have nothing to disclose.
Databáze: MEDLINE
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