3D analysis of bone mineral density in a cohort: age- and sex-related differences.

Autor: Valero C; Department of Internal Medicine, University Hospital Marqués de Valdecilla, Santander, Spain. mirvdc@humv.es.; University of Cantabria, IDIVAL, Santander, Spain. mirvdc@humv.es., Olmos JM; Department of Internal Medicine, University Hospital Marqués de Valdecilla, Santander, Spain.; University of Cantabria, IDIVAL, Santander, Spain., Humbert L; Galgo Medical, Barcelona, Spain., Castillo J; Department of Internal Medicine, University Hospital Marqués de Valdecilla, Santander, Spain.; University of Cantabria, IDIVAL, Santander, Spain., Hernández JL; Department of Internal Medicine, University Hospital Marqués de Valdecilla, Santander, Spain.; University of Cantabria, IDIVAL, Santander, Spain., Martínez J; Department of Internal Medicine, University Hospital Marqués de Valdecilla, Santander, Spain.; University of Cantabria, IDIVAL, Santander, Spain., Macías JG; Department of Internal Medicine, University Hospital Marqués de Valdecilla, Santander, Spain.; University of Cantabria, IDIVAL, Santander, Spain.
Jazyk: angličtina
Zdroj: Archives of osteoporosis [Arch Osteoporos] 2021 Jun 02; Vol. 16 (1), pp. 80. Date of Electronic Publication: 2021 Jun 02.
DOI: 10.1007/s11657-021-00921-w
Abstrakt: Women have lower areal BMD (g/cm 2 ) than men; however, the women have smaller-size bones. Our study showed that women ≤ 59 years have a hip volumetric BMD by DXA 3D similar to that of men of the same age. This makes us think about the importance of taking into account bone size at the time of analyzing the sex-related differences in bone mass.
Purpose: Women have lower areal BMD (g/cm 2 ) than men; however, these studies do not take into account that women have smaller-size bones. Recently, three-dimensional (3D) modeling methods were proposed to analyze volumetric BMD (vBMD). We want to determine the values of vBMD at the hip by DXA-based 3D modeling in a cohort of people in order to know the age- and sex-related differences.
Methods: A total of 2647 people of both sexes (65% women) were recruited from a large cohort (Camargo cohort, Santander, Spain). 3D-SHAPER® software (version 2.8, Galgo Medical, Barcelona, Spain) was used to derive 3D analysis from the hip DXA scans at baseline RESULTS: The differences were less pronounced for vBMD (cortical sBMD 9.3%, trabecular vBMD 6.4%, integral vBMD 2.2%) compared to aBMD (FN aBMD 11.4% and TH aBMD 13.3%). After stratifying by age (≤ 59 years, 60-69 years, 70-79 years, and ≥ 80 years), we observed in ≤ 59 years that aBMD was lower in women compared to men, at FN (0.758 [0.114] g/cm 2 vs. 0.833 [0.117] g/cm 2 ; p = 1.4 × 10 -20 ) and TH (0.878 [0.117] g/cm 2 vs. 0.990 [0.119] g/cm 2 ; p = 4.1 × 10 -40 ). Nevertheless, no statistically significant difference was observed for integral vBMD (331 [58] mg/cm 3 in women and 326 [51] mg/cm 3 in men; p = 0.19) and trabecular vBMD (190 [41] mg/cm 3 in women and 195 [39] mg/cm 3 in men; p = 0.20).
Conclusion: Our results make us think about the importance of taking into account bone size at the time of analyzing the sex-related differences in bone mass.
Databáze: MEDLINE
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