| Autor: |
Tram LH; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Thu Huong T; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Thi Thuy L; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Van Thong N; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Tuan Anh N; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Hoang Minh N; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Thu Ha T; Intellectual Property Office of Vietnam, Hanoi, Vietnam., Anh Dung D; Intellectual Property Office of Vietnam, Hanoi, Vietnam., Thao NP; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Thuong PT; Biotechnology Department, Vietnam - Korea Institute of Science and Technology, Hanoi, Vietnam., Le DD; Division of Computational Physics, Institute for Computational Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Hiep ND; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Shin HJ; Department of Marine Biotechnology, University of Science and Technology (UST), Daejeon, Korea.; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan, Korea. |
| Abstrakt: |
A series of schiartane C 29 nortriterpenoids with 5/5/7/6/5 membered consecutive rings ( 1 ‒ 5 ) with an unique schinortriterpenoid skeleton including a new, kadcoccilactone V ( 1 ), together with four known ones ( 2 ‒ 5 ) and three known triterpenoids ( 6 ‒ 8 ) were identified from stems of Kadsura coccinea (Lem.) A. C. Smith. The structures of 1 and known compounds were elucidated by interpretation of 1D and 2D NMR, and HR-ESI-MS data as well as comparing those data in the literature. All the isolated compounds were examined for cytotoxic effects against six human cancer cell lines [(HCT-15 (colon), NUGC-3 (stomach), NCI-H23 (lung), ACHN (renal), PC-3 (prostate), and MDA-MB-231 (breast)]. Among them, compound 6 showed potent cytotoxicity against NCI-H23 (GI 50 1.28 µM) and NUGC-3 (GI 50 1.28 µM), and significantly inhibited on PC-3, MDA-MB-231, ACHN, HCT-15 with GI 50 values around 2.33 to 2.67 µM. |
