Corneal endothelial cell density in patients receiving chemotherapy.

Autor: Gallagher SP; Department of Psychology, Millersville University of Pennsylvania, Millersville, PA, USA., Halpern BL; Eye Doctors of Lancaster, Lancaster, PA, USA., Sivendran S; Penn Medicine Lancaster General Health, Lancaster, PA, USA.; Hematology/Oncology Medical Specialists, Lancaster, PA, USA.
Jazyk: angličtina
Zdroj: Cutaneous and ocular toxicology [Cutan Ocul Toxicol] 2021 Sep; Vol. 40 (3), pp. 252-256. Date of Electronic Publication: 2021 Jun 16.
DOI: 10.1080/15569527.2021.1937206
Abstrakt: Purpose: This study aimed to determine if the corneal endothelium was affected by chemotherapy.
Methods: Chemotherapy patients were recruited to undergo specular microscopy before treatment and again at 1- and 2-year follow-up visits. One eye per patient, per follow-up, was selected for comparison to baseline.
Results: Forty-six volunteers completed baseline and at least one follow-up assessment. From 51 eyes, there was no significant change in endothelial cell density for 41 eyes assessed at one year ( M D = 0.73%, 95% CI -1.33 to 2.78%) and 18 eyes at two years ( M D = 0.31%, 95% CI -3.53 to 4.15%).
Conclusion: Although other studies have shown that chemotherapy can adversely affect the corneal epithelium, this study showed no measurable change in endothelial cell density.
Databáze: MEDLINE
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