| Autor: |
Liu XD; Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 100093, China., Wang C; Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 100093, China., Meng XJ; Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 100093, China., Pan XF; Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 100093, China., Li J; Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 100093, China., Niu DS; Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 100093, China., Chen ZJ; Peking University Health Science Center, Beijing 100191, China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases [Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi] 2021 May 20; Vol. 39 (5), pp. 328-332. |
| DOI: |
10.3760/cma.j.cn121094-20200323-00149 |
| Abstrakt: |
Objective: To investigate the effects of titanium dioxide nanoparticles (TiO(2) NPs) on urine metabolites in occupationally exposure people based on metabolomics technology, and to explore the mechanism of early health effects of TiO(2) NPs on occupational exposure. Methods: In October 2019, the TiO(2) NPs occupational exposure population was selected as the research object, of which 64 people were in the exposure group who had been engaged in TiO(2) NPs exposure positions for more than 1 year; the control group was 62 people, who were logistics administrative staff of the same company. The urine of the research subjects before class was collected, using the ultra-high performance liquid chromatography time-of-flight mass spectrometer to collect the metabolism data of the urine, Progenesis QI software for data preprocessing and metabolite identification, SIMCA-P software for the principal component analysis of the data and potential biomarkers screening, MetaboAnalyst 4.0 software for metabolic pathway enrichment analysis. Results: The urine metabolism profile of workers in the exposure group was different from the control group, and 44 potential biomarkers were screened and identified. These potential biomarkers were significantly enriched in three pathways ( P <0.05) , namely D-arginine and D-ornithine metabolism pathway, nitrogen metabolism pathway and D-glutamine and D-glutamate metabolism pathways. Conclusion: The occupational exposure of TiO(2) NPs can affect the concentration of metabolites in people urine and metabolic pathways, which provides a direction for the study of occupational hazard mechanisms of TiO(2) NPs and the monitoring of health risks. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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