Camu-Camu Fruit Extract Inhibits Oxidative Stress and Inflammatory Responses by Regulating NFAT and Nrf2 Signaling Pathways in High Glucose-Induced Human Keratinocytes.

Autor: Do NQ; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea., Zheng S; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea., Park B; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea., Nguyen QTN; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea., Choi BR; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Korea., Fang M; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea., Kim M; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea.; Snow White Factory Co., Ltd., 807 Nonhyeonro, Gangnam-gu, Seoul 06032, Korea., Jeong J; Snow White Factory Co., Ltd., 807 Nonhyeonro, Gangnam-gu, Seoul 06032, Korea., Choi J; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea., Yang SJ; Gu Star Co., Ltd., 7/F, Cheongho B/D, 19, Eonju-ro 148-gil, Gangnam-gu, Seoul 06054, Korea., Yi TH; Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-Daero, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Korea.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2021 May 26; Vol. 26 (11). Date of Electronic Publication: 2021 May 26.
DOI: 10.3390/molecules26113174
Abstrakt: Myrciaria dubia (HBK) McVaugh (camu-camu) belongs to the family Myrtaceae. Although camu-camu has received a great deal of attention for its potential pharmacological activities, there is little information on the anti-oxidative stress and anti-inflammatory effects of camu-camu fruit in skin diseases. In the present study, we investigated the preventative effect of 70% ethanol camu-camu fruit extract against high glucose-induced human keratinocytes. High glucose-induced overproduction of reactive oxygen species (ROS) was inhibited by camu-camu fruit treatment. In response to ROS reduction, camu-camu fruit modulated the mitogen-activated protein kinases (MAPK)/activator protein-1 (AP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and nuclear factor of activated T cells (NFAT) signaling pathways related to inflammation by downregulating the expression of proinflammatory cytokines and chemokines. Furthermore, camu-camu fruit treatment activated the expression of nuclear factor E2-related factor 2 (Nrf2) and subsequently increased the NAD(P)H:quinone oxidoreductase1 (NQO1) expression to protect keratinocytes against high-glucose-induced oxidative stress. These results indicate that camu-camu fruit is a promising material for preventing oxidative stress and skin inflammation induced by high glucose level.
Databáze: MEDLINE
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