| Autor: |
Zamay TN; Laboratory for Biomolecular and Medical Technologies, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, 660029 Krasnoyarsk, Russia.; Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk, Russia., Prokopenko VS; Institute of Physics and Informatics, Astafiev Krasnoyarsk State Pedagogical University, 660049 Krasnoyarsk, Russia., Zamay SS; Molecular Electronics Department, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk, Russia., Lukyanenko KA; Laboratory for Biomolecular and Medical Technologies, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, 660029 Krasnoyarsk, Russia.; Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk, Russia.; School of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodny pr., 660041 Krasnoyarsk, Russia., Kolovskaya OS; Laboratory for Biomolecular and Medical Technologies, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, 660029 Krasnoyarsk, Russia.; Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk, Russia., Orlov VA; School of Engineering Physics and Radio Electronics, Siberian Federal University, 79 Svobodny pr., 660041 Krasnoyarsk, Russia.; Kirensky Institute of Physics Federal Research Center KSC Siberian Branch Russian Academy of Sciences, Akademgorodok 50, bld. 38, 660036 Krasnoyarsk, Russia., Zamay GS; Laboratory for Biomolecular and Medical Technologies, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, 660029 Krasnoyarsk, Russia.; Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk, Russia., Galeev RG; JSC «NPP «Radiosviaz», 660021 Krasnoyarsk, Russia., Narodov AA; Traumatology Orthopedics and Neurosurgery Department, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, 660029 Krasnoyarsk, Russia., Kichkailo AS; Laboratory for Biomolecular and Medical Technologies, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenecky, 660029 Krasnoyarsk, Russia.; Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center, Krasnoyarsk Science Center Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk, Russia. |
| Abstrakt: |
Magnetomechanical therapy is one of the most perspective directions in tumor microsurgery. According to the analysis of recent publications, it can be concluded that a nanoscalpel could become an instrument sufficient for cancer microsurgery. It should possess the following properties: (1) nano- or microsized; (2) affinity and specificity to the targets on tumor cells; (3) remote control. This nano- or microscalpel should include at least two components: (1) a physical nanostructure (particle, disc, plates) with the ability to transform the magnetic moment to mechanical torque; (2) a ligand-a molecule (antibody, aptamer, etc.) allowing the scalpel precisely target tumor cells. Literature analysis revealed that the most suitable nanoscalpel structures are anisotropic, magnetic micro- or nanodiscs with high-saturation magnetization and the absence of remanence, facilitating scalpel remote control via the magnetic field. Additionally, anisotropy enhances the transmigration of the discs to the tumor. To date, four types of magnetic microdiscs have been used for tumor destruction: synthetic antiferromagnetic P-SAF (perpendicular) and SAF (in-plane), vortex Py, and three-layer non-magnetic-ferromagnet-non-magnetic systems with flat quasi-dipole magnetic structures. In the current review, we discuss the biological effects of magnetic discs, the mechanisms of action, and the toxicity in alternating or rotating magnetic fields in vitro and in vivo. Based on the experimental data presented in the literature, we conclude that the targeted and remotely controlled magnetic field nanoscalpel is an effective and safe instrument for cancer therapy or theranostics. |
