| Autor: |
Cadelis MM; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Gordon H; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Grey A; Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Geese S; Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Mulholland DR; Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Weir BS; Manaaki Whenua - Landcare Research, Private Bag 92170, Auckland 1142, New Zealand., Copp BR; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Wiles S; Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. |
| Abstrakt: |
Fungi have become an invaluable source of bioactive natural products, with more than 5 million species of fungi spanning the globe. Fractionation of crude extract of Neodidymelliopsis sp., led to the isolation of a novel polyketide, (2 Z )-cillifuranone ( 1 ) and five previously reported natural products, (2 E )-cillifuranone ( 2 ), taiwapyrone ( 3 ), xylariolide D ( 4 ), pachybasin ( 5 ), and N -(5-hydroxypentyl)acetamide ( 6 ). It was discovered that (2 Z )-cillifuranone ( 1 ) was particularly sensitive to ambient temperature and light resulting in isomerisation to (2 E )-cillifuranone ( 2 ). Structure elucidation of all the natural products were conducted by NMR spectroscopic techniques. The antimicrobial activity of 2 , 3 , and 5 were evaluated against a variety of bacterial and fungal pathogens. A sodium [1- 13 C] acetate labelling study was conducted on Neodidymelliopsis sp. and confirmed that pachybasin is biosynthesised through the acetate polyketide pathway. |
