| Autor: |
Alshabanah LA; Chemistry Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Hagar M; Chemistry Department, College of Sciences, Taibah University, Yanbu 30799, Saudi Arabia.; Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21321, Egypt., Al-Mutabagani LA; Chemistry Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Abozaid GM; Pharmaceutical Practice Department, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Abdallah SM; Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab (CAPL), Agricultural Research Center (ARC), Giza 12611, Egypt., Shehata N; Center of Smart Materials Nanotechnology and Photonics (CSMNP), Smart CI Research Center, Alexandria University, Alexandria 21544, Egypt.; Department of Engineering Mathematics and Physics, Faculty of Engineering, Alexandria University, Alexandria 21544, Egypt.; USTAR Bio Innovations Center, Faculty of Science, Utah State University, Logan, UT 84341, USA.; Department of Physics, School of Engineering, Kuwait College of Science and Technology (KCST), Doha Superior Rd., Jahraa 13133, Kuwait., Ahmed H; Chemistry Department, College of Sciences, Taibah University, Yanbu 30799, Saudi Arabia.; Department of Chemistry, Faculty of Science, Cairo University, Cairo 12613, Egypt., Hassanin AH; Center of Smart Materials Nanotechnology and Photonics (CSMNP), Smart CI Research Center, Alexandria University, Alexandria 21544, Egypt.; Materials Science & Engineering Department, School of Innovative Design Engineering, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City, Alexandria 21934, Egypt.; Department of Textile Engineering, Faculty of Engineering, Alexandria University, Alexandria 21544, Egypt. |
| Abstrakt: |
In this research work, nanofibrous hybrids are manufactured, characterized, and assessed as active antiviral and antibacterial membranes. In more detail, both polyvinyl alcohol (PVA) and thermoplastic polyurethane (TPU) nanofibrous (NF) membranes and their composites with embedded silver nanoparticles (Ag NPs) are manufactured by an electrospinning process. Their morphological structures have been investigated by a scanning electron microscope (SEM) which revealed a homogenous distribution and almost beads-free fibers in all manufactured samples. Characterization with spectroscopic tools has been performed and proved the successful manufacturing of Ag-incorporated PVA and TPU hybrid nanofibers. The crystalline phase of the nanofibers has been determined using an X-ray diffractometer (XRD) whose patterns showed their crystalline nature at an angle value (2θ) of less than 20°. Subsequent screening of both antiviral and antibacterial potential activities of developed nanohybrid membranes has been explored against different viruses, including SARS-Cov-2 and some bacterial strains. As a novel approach, the current work highlights potential effects of several polymeric hybrids on antiviral and antibacterial activities particularly against SARS-Cov-2. Moreover, two types of polymers have been tested and compared; PVA of excellent biodegradable and hydrophilic properties, and TPU of excellent mechanical, super elasticity, hydrophobicity, and durability properties. Such extreme polymers can serve a wide range of applications such as PPE, filtration, wound healing, etc. Consequently, assessment of their antiviral/antibacterial activities, as host matrices for Ag NPs, is needed for different medical applications. Our results showed that TPU-Ag was more effective than PVA-Ag as HIV-1 antiviral nanohybrid as well as in deactivating spike proteins of SARS-Cov-2. Both TPU-Ag and PVA-Ag nanofibrous membranes were found to have superior antimicrobial performance by increasing Ag concentration from 2 to 4 wt.%. Additionally, the developed membranes showed acceptable physical and mechanical properties along with both antiviral and antibacterial activities, which can enable them to be used as a promising functional layer in Personal Protective Equipment (PPE) such as (surgical gowns, gloves, overshoes, hair caps, etc.). Therefore, the developed functional membranes can support the decrease of both coronavirus spread and bacterial contamination, particularly among healthcare professionals within their workplace settings. |
