Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Autor: Van Puyvelde H; Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France.; Research Foundation-Flanders (FWO), 1000 Brussels, Belgium., Papadimitriou N; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France., Clasen J; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London W2 1PG, UK., Muller D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London W2 1PG, UK., Biessy C; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France., Ferrari P; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France., Halkjær J; Diet, Genes and Environment, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark., Overvad K; Department of Public Health, Aarhus University, DK-8000 Aarhus C, Denmark., Tjønneland A; Diet, Genes and Environment, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.; Department of Public Health, University of Copenhagen, DK-2200 Copenhagen, Denmark., Fortner RT; Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany., Katzke V; Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.; Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany., Chiodini P; Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Masala G; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, 50139 Firenze, Italy., Pala V; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian, 1, 20133 Milano, Italy., Sacerdote C; Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, 10126 Turin, Italy., Tumino R; Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), 97100 Ragusa, Italy., Bakker MF; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Agudo A; Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Institut Català d'Oncologa, 08908 L'Hospitalet de Llobregat, Barcelona, Spain., Ardanaz E; Navarra Public Health Institute, 31003 Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.; CIBER Epidemiology and Public Health CIBERESP, 28029 Madrid, Spain., Chirlaque López MD; CIBER Epidemiology and Public Health CIBERESP, 28029 Madrid, Spain.; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30120 Murcia, Spain., Sánchez MJ; CIBER Epidemiology and Public Health CIBERESP, 28029 Madrid, Spain.; Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain.; Instituto de Investigación Biosanitaria ibs., 18014 Granada, Spain.; Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, Spain., Ericson U; Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, 205 02 Malmö, Sweden., Gylling B; Unit Pathology, Department of Medical Biosciences, Umeå Universitet, 901 85 Umeå, Sweden., Karlsson T; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden., Manjer J; Department of Surgery, Skåne University Hospital Malmö, Lund University, Bröstmottagningen, 214 28 Malmö, Sweden., Schmidt JA; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 LF7, UK., Nicolas G; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France., Casagrande C; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France., Weiderpass E; Office of the Director, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France., Heath AK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London W2 1PG, UK., Godderis L; Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.; IDEWE (Externe dienst voor Preventie en Bescherming op het Werk), 3001 Heverlee, Belgium., Van Herck K; Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium., De Bacquer D; Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium., Gunter MJ; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France., Huybrechts I; Nutrition and Metabolism Section, International Agency for Research on Cancer, CEDEX 08, 69372 Lyon, France.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2021 May 28; Vol. 13 (6). Date of Electronic Publication: 2021 May 28.
DOI: 10.3390/nu13061843
Abstrakt: (1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
Databáze: MEDLINE