Association between Pre-Diagnostic Serum Bile Acids and Hepatocellular Carcinoma: The Singapore Chinese Health Study.

Autor: Thomas CE; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Luu HN; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Wang R; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Xie G; University of Hawaii Cancer Center, Honolulu, HI 96813, USA., Adams-Haduch J; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Jin A; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore., Jia W; University of Hawaii Cancer Center, Honolulu, HI 96813, USA., Behari J; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.; Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2021 May 28; Vol. 13 (11). Date of Electronic Publication: 2021 May 28.
DOI: 10.3390/cancers13112648
Abstrakt: Hepatocellular carcinoma (HCC) is a commonly diagnosed malignancy with poor prognosis. Rising incidence of HCC may be due to rising prevalence of metabolic dysfunction-associated fatty liver disease, where altered bile acid metabolism may be implicated in HCC development. Thirty-five bile acids were quantified using ultra-performance liquid chromatography triple-quadrupole mass spectrometry assays in pre-diagnostic serum of 100 HCC cases and 100 matched controls from the Singapore Chinese Health Study. Conditional logistic regression was used to assess associations for bile acid levels with risk of HCC. Conjugated primary bile acids were significantly elevated whereas the ratios of secondary bile acids over primary bile acids were significantly lower in HCC cases than controls. The respective odds ratios and 95% confidence intervals of HCC were 6.09 (1.75-21.21) for highest vs. lowest tertile of cholic acid species and 30.11 (5.88-154.31) for chenodeoxycholic acid species. Doubling ratio of taurine-over glycine-conjugated chenodeoxycholic acid was associated significantly with 40% increased risk of HCC whereas doubling ratio of secondary over primary bile acid species was associated with 30-40% reduced risk of HCC. In conclusion, elevated primary bile acids and taurine over glycine-conjugated ratios were strongly associated with HCC risk whereas the ratios of secondary bile acids over primary bile acids were inversely associated with HCC risk.
Databáze: MEDLINE
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