| Autor: |
Perumalsamy S; Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy, University of Malaya, Kuala Lumpur 50603, Malaysia., Wan Ahmad WA; Cardiology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia., Zaman Huri H; Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy, University of Malaya, Kuala Lumpur 50603, Malaysia.; Clinical Investigation Centre (CIC), University Malaya Medical Centre, Petaling Jaya 59100, Malaysia. |
| Jazyk: |
angličtina |
| Zdroj: |
Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2021 May 23; Vol. 9 (6). Date of Electronic Publication: 2021 May 23. |
| DOI: |
10.3390/healthcare9060623 |
| Abstrakt: |
(1) Background: Chemerin, or the RARRES2 ( Retinoic Acid Receptor Responder 2 ) gene, is found to be associated with an increased incidence of insulin resistance, endothelial dysfunction, type 2 diabetes (T2D), and coronary artery disease (CAD). This study investigates associations of RARRES2 rs17173608 with insulin resistance and the severity of CAD in non-obese T2D patients in relation to the clinical and genetic factors. (2) Methods: A total of 300 patients with T2D and CAD were recruited in this study. The associations of insulin resistance and the severity of CAD with RARRES2 rs17173608 and clinical factors were assessed. The genotyping procedures were performed using the TaqMan method. The significant associations ( p ≤ 0.05) from preliminary tests were employed to carry out the secondary analysis. (3) Results: RARRES2 rs17173608 (TT, TG, and GG polymorphisms in the preliminary analysis; TG and GG polymorphisms in a secondary analysis) was associated with insulin resistance and the severity of CAD in both the preliminary and secondary analysis (all p -values were < 0.05). Additionally, in the secondary analysis, FPG and ACEI were also associated with insulin resistance and the severity of CAD (all p -values were < 0.05). (4) Conclusion: From the preliminary findings, rs17173608 is a significant predictor of insulin resistance and the severity of CAD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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