| Autor: |
Puchkova LV; International Research Laboratory of Trace Elements Metabolism, ADTS Institute, RC AFMLCS, ITMO University, 197101 St. Petersburg, Russia., Kiseleva IV; Department of Virology, Institute of Experimental Medicine, 197376 St. Petersburg, Russia., Polishchuk EV; Telethon Institute of Genetics and Medicine, Pozzuoli, 80078 Naples, Italy., Broggini M; Istituto di Ricerche Farmacologiche 'Mario Negri', IRCCS, 20156 Milan, Italy., Ilyechova EY; International Research Laboratory of Trace Elements Metabolism, ADTS Institute, RC AFMLCS, ITMO University, 197101 St. Petersburg, Russia.; Department of Molecular Genetics, Institute of Experimental Medicine, 197376 St. Petersburg, Russia. |
| Abstrakt: |
Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral particles, as well as genetic constructs carrying viral proteins or information about them, are used as an antigen. However, the viral genome is very evolutionary labile and changes continuously. Second, chemical agents are used during infection and inhibit the function of a number of viral proteins. However, these drugs lose their effectiveness because the virus can rapidly acquire resistance to them. The third is the search for points in the host metabolism the effect on which would suppress the replication of the virus but would not have a significant effect on the metabolism of the host. Here, we consider the possibility of using the copper metabolic system as a target to reduce the severity of influenza infection. This is facilitated by the fact that, in mammals, copper status can be rapidly reduced by silver nanoparticles and restored after their cancellation. |
