Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy-3-Year Longitudinal Study.

Autor: Marques IP; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal., Kubach S; Research and Development, Carl Zeiss Meditec, Dublin, CA 94568, USA., Santos T; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal., Mendes L; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal., Madeira MH; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal., de Sisternes L; Research and Development, Carl Zeiss Meditec, Dublin, CA 94568, USA., Tavares D; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal., Santos AR; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal.; Department of Orthoptics, School of Health, Polytechnic of Porto, 4200-072 Porto, Portugal., Lewis W; Research and Development, Carl Zeiss Meditec, Dublin, CA 94568, USA., Lobo C; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), 3000-075 Coimbra, Portugal., Durbin MK; Research and Development, Carl Zeiss Meditec, Dublin, CA 94568, USA., Cunha-Vaz J; AIBILI-Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 May 25; Vol. 10 (11). Date of Electronic Publication: 2021 May 25.
DOI: 10.3390/jcm10112296
Abstrakt: To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. Results: A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale ( p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression.
Databáze: MEDLINE
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