| Autor: |
Pacella V; Npsy.Lab-VR, Dipartimento di Scienze Umane, Università di Verona, Lungadige Porta Vittoria, 17-37129 Verona, Italy.; Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, 75006 Paris, France.; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, 33076 Bordeaux, France., Ricciardi GK; Neuroradiology, AOUVR Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani, 1-37126 Verona, Italy., Bonadiman S; IRCSS, Ospedale Sacro Cuore-Don Calabria, Via Rizzardi, 4-37024 Negrar di Valpolicella, Italy., Verzini E; IRCSS, Ospedale Sacro Cuore-Don Calabria, Via Rizzardi, 4-37024 Negrar di Valpolicella, Italy., Faraoni F; Npsy.Lab-VR, Dipartimento di Scienze Umane, Università di Verona, Lungadige Porta Vittoria, 17-37129 Verona, Italy., Scandola M; Npsy.Lab-VR, Dipartimento di Scienze Umane, Università di Verona, Lungadige Porta Vittoria, 17-37129 Verona, Italy., Moro V; Npsy.Lab-VR, Dipartimento di Scienze Umane, Università di Verona, Lungadige Porta Vittoria, 17-37129 Verona, Italy. |
| Abstrakt: |
The anarchic hand syndrome refers to an inability to control the movements of one's own hand, which acts as if it has a will of its own. The symptoms may differ depending on whether the brain lesion is anterior, posterior, callosal or subcortical, but the relative classifications are not conclusive. This study investigates the role of white matter disconnections in a patient whose symptoms are inconsistent with the mapping of the lesion site. A repeated neuropsychological investigation was associated with a review of the literature on the topic to identify the frequency of various different symptoms relating to this syndrome. Furthermore, an analysis of the neuroimaging regarding structural connectivity allowed us to investigate the grey matter lesions and white matter disconnections. The results indicated that some of the patient's symptoms were associated with structures that, although not directly damaged, were dysfunctional due to a disconnection in their networks. This suggests that the anarchic hand may be considered as a disconnection syndrome involving the integration of multiple antero-posterior, insular and interhemispheric networks. In order to comprehend this rare syndrome better, the clinical and neuroimaging data need to be integrated with the clinical reports available in the literature on this topic. |
