The Potential Role of Polyphenols in Modulating Mitochondrial Bioenergetics within the Skeletal Muscle: A Systematic Review of Preclinical Models.

Autor: Mthembu SXH; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Dludla PV; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa., Ziqubu K; Department of Biochemistry, Faculty of Natural and Agricultural Sciences, Mafikeng Campus, North West University, Private Bag X 2046, Mmabatho 2735, South Africa., Nyambuya TM; Department of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Windhoek 9000, Namibia.; School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa., Kappo AP; Department of Biochemistry, Faculty of Science, Kingsway Campus, University of Johannesburg, Auckland Park 2006, South Africa., Madoroba E; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Nyawo TA; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa., Nkambule BB; School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa., Silvestri S; Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy., Muller CJF; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa., Mazibuko-Mbeje SE; Department of Biochemistry, Faculty of Natural and Agricultural Sciences, Mafikeng Campus, North West University, Private Bag X 2046, Mmabatho 2735, South Africa.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2021 May 10; Vol. 26 (9). Date of Electronic Publication: 2021 May 10.
DOI: 10.3390/molecules26092791
Abstrakt: Polyphenols are naturally derived compounds that are increasingly being explored for their various health benefits. In fact, foods that are rich in polyphenols have become an attractive source of nutrition and a potential therapeutic strategy to alleviate the untoward effects of metabolic disorders. The last decade has seen a rapid increase in studies reporting on the bioactive properties of polyphenols against metabolic complications, especially in preclinical models. Various experimental models involving cell cultures exposed to lipid overload and rodents on high fat diet have been used to investigate the ameliorative effects of various polyphenols against metabolic anomalies. Here, we systematically searched and included literature reporting on the impact of polyphenols against metabolic function, particularly through the modulation of mitochondrial bioenergetics within the skeletal muscle. This is of interest since the skeletal muscle is rich in mitochondria and remains one of the main sites of energy homeostasis. Notably, increased substrate availability is consistent with impaired mitochondrial function and enhanced oxidative stress in preclinical models of metabolic disease. This explains the general interest in exploring the antioxidant properties of polyphenols and their ability to improve mitochondrial function. The current review aimed at understanding how these compounds modulate mitochondrial bioenergetics to improve metabolic function in preclinical models on metabolic disease.
Databáze: MEDLINE
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