| Autor: |
Colombo A; Division of Radiology, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy., Bombelli L; Division of Radiology, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy., Summers PE; Division of Radiology, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy., Saia G; Division of Radiology, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy., Zugni F; Division of Radiology, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy., Marvaso G; Division of Radiotherapy, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy., Grimm R; MR Applications Pre-Development, Siemens Healthcare, 91052 Erlangen, Germany., Jereczek-Fossa BA; Division of Radiotherapy, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy., Padhani AR; Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood HA6 2RN, UK., Petralia G; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.; Precision Imaging and Research Unit, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy. |
| Abstrakt: |
We aimed to describe the relationships between the relative fat fraction (%FF), muscle-normalized diffusion-weighted (DW) image signal intensity and water apparent diffusion coefficient (ADC), sex and age for normal bone marrow, in the normal population. Our retrospective cohort consisted of 100 asymptomatic individuals, equally divided by sex and 10-year age groups, who underwent whole-body MRI at 1.5 T for early cancer detection. Semi-automated segmentation of global bone marrow volume was performed using the DW images and the resulting segmentation masks were projected onto the ADC and %FF maps for extraction of parameter values. Differences in the parameter values between sexes at age ranges were assessed using the Mann-Whitney and Kruskal-Wallis tests. The Spearman correlation coefficient r was used to assess the relationship of each imaging parameter with age, and of %FF with ADC and normalized DW signal intensity values. The average %FF of normal bone marrow was 65.6 ± 7.2%, while nSI b50 , nSI b900 and ADC were 1.7 ± 0.5, 3.2 ± 0.9 and 422 ± 67 μm 2 /s, respectively. The bone marrow %FF values increased with age in both sexes (r = 0.63 and r = 0.64, respectively, p < 0.001). Values of nSI b50 and nSI b900 were higher in younger women compared to men of the same age groups ( p < 0.017), but this difference decreased with age. In our cohort of asymptomatic individuals, the values of bone marrow relative %FF, normalized DW image signal intensity and ADC indicate higher cellularity in premenopausal women, with increasing bone marrow fat with aging in both sexes. |
