Brivaracetam Retention Rate and Seizure Outcomes in Patients with Drug-Resistant Focal Epilepsy Included in the Medical Need Program in Belgium: A Real-World, Multicenter, Chart Review.

Autor: Depondt C; Reference Center for the Treatment of Refractory Epilepsy, Hôpital Erasme, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium., Van Paesschen W; Refractory Epilepsy Center, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium., van Rijckevorsel K; Centre Hospitalier Neurologique William Lennox, Allée de Clerlande 6, 1340, Ottignies, Belgium., Leunikava I; UCB Pharma, Alfred-Nobel-Straße 10, 40789, Monheim am Rhein, Germany., Ferrière F; UCB Pharma, Allée de la Recherche 60, 1070, Brussels, Belgium. france.ferriere@ucb.com.
Jazyk: angličtina
Zdroj: Drugs - real world outcomes [Drugs Real World Outcomes] 2021 Sep; Vol. 8 (3), pp. 407-415. Date of Electronic Publication: 2021 May 31.
DOI: 10.1007/s40801-021-00246-7
Abstrakt: Background: New treatments are needed for patients with drug-resistant epilepsy to improve seizure control without decreasing quality of life.
Objective: In Belgium, a Medical Need Program (MNP) was initiated to make a new antiepileptic drug (brivaracetam; high-affinity synaptic vesicle protein 2A ligand) available as adjunctive therapy to treat focal seizures in patients failing treatment with three or more different antiepileptic drugs. This is a real-world chart review of the majority of patients (71%) enrolled in the MNP.
Patients and Methods: Retention and seizure outcomes of brivaracetam adjunctive treatment were evaluated in 175 patients aged ≥ 16 years enrolled in the MNP between June 2016 and May 2017 at six centers; 95.4% were previously/concomitantly treated with levetiracetam. Safety events data were also collected.
Results: In this highly drug-resistant population, 85.8%, 73.9%, and 64.9% of patients remained on brivaracetam, while seizure frequency decreased from baseline in 32.0%, 37.1%, and 37.3% of patients after 3, 6, and 9 months' treatment, respectively. Patients achieving 3-month seizure freedom increased from 3.2% after 3 months' treatment to 10.2% and 10.7% after 6 and 9 months' treatment, respectively. Six-month seizure freedom was achieved by 5.7% of patients at any time. Qualitative evaluation of seizures by physicians demonstrated 44.2%, 38.8%, and 43.2% of patients improved and 42.8%, 50.9%, and 50.6% remained unchanged during 3, 6, and 9 months' follow-up, respectively. No safety signals were identified.
Conclusions: Retention was high during 9 months of brivaracetam treatment in drug-resistant patients, including those previously/concomitantly treated with levetiracetam; 3-month seizure freedom increased from 3.2% after 3 months to 10.7% after 9 months of treatment.
(© 2021. The Author(s).)
Databáze: MEDLINE
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