Effectiveness of the HCV blood screening strategy through eighteen years of surveillance of HCV infection in blood donors in France.

Autor:	Cappy P; Institut National de la Transfusion Sanguine (INTS), Département des Agents Transmissibles par le Sang, Centre National de Référence Risques Infectieux Transfusionnels, Paris, France., Boizeau L; Institut National de la Transfusion Sanguine (INTS), Département des Agents Transmissibles par le Sang, Centre National de Référence Risques Infectieux Transfusionnels, Paris, France., Candotti D; Institut National de la Transfusion Sanguine (INTS), Département des Agents Transmissibles par le Sang, Centre National de Référence Risques Infectieux Transfusionnels, Paris, France., Caparros R; Institut National de la Transfusion Sanguine (INTS), Département des Agents Transmissibles par le Sang, Centre National de Référence Risques Infectieux Transfusionnels, Paris, France., Lucas Q; Institut National de la Transfusion Sanguine (INTS), Département des Agents Transmissibles par le Sang, Centre National de Référence Risques Infectieux Transfusionnels, Paris, France., Garrabe E; Centre de Transfusion des Armées, Clamart, France., Martinaud C; Centre de Transfusion des Armées, Clamart, France., Le Cam S; Etablissement Français du Sang, La Plaine St-Denis, France., Gallian P; Etablissement Français du Sang, La Plaine St-Denis, France.; Unité des Virus Émergents, (UVE: Aix-Marseille Univ-IRD 190-INSERM 1207-IHU Méditerranée Infection), Marseille, France., Morel P; Etablissement Français du Sang, La Plaine St-Denis, France.; UMR 1098 RIGHT, Inserm, EFS, Université de Franche-Comté, Besançon, France., Pillonel J; Santé Publique France, Saint Maurice, France., Laperche S; Institut National de la Transfusion Sanguine (INTS), Département des Agents Transmissibles par le Sang, Centre National de Référence Risques Infectieux Transfusionnels, Paris, France.
Jazyk:	angličtina
Zdroj:	Blood transfusion = Trasfusione del sangue [Blood Transfus] 2022 Jan; Vol. 20 (1), pp. 1-7. Date of Electronic Publication: 2021 May 12.
DOI:	10.2450/2021.0032-21
Abstrakt:	Background: The question of maintaining blood screening based on both Hepatitis C virus (HCV) infection antibodies (Ab) and Nucleic Acid Testing (NAT) has been raised in several countries. The French blood donor surveillance database was used to address this issue. Materials and Methods: In France, HCV-NAT was implemented in mini pools (MP) in 2001 and in individual testing (ID) in 2010. HCV-positive donations are further investigated including detection of RNA with an alternative polymerase chain reaction assay: Amplicor HCV v2.0 (Roche; LOD95 50 IU/mL) from 2001 to 2006 and CobasTaqMan (CTM) HCV 2.0 assay (Roche; LOD95 9.3 IU/mL) since 2007. Results: From 2001 to 2018, 3,058/48.8 million donations were confirmed HCV positive: 64.4% were Ab+/NAT+, 35.1% Ab+/NAT- and 0.5% Ab-/NAT+. From 2001 to 2018, the NAT yield decreased from 0.65 per million donations to 0, and NAT+ donations dropped from 77% to 46% of the total of HCV donations. 2,491/3,058 were further tested for HCV-RNA: 1,032 (816 NAT+, 216 NAT-) with Amplicor and 1,459 (897 NAT+, 562 NAT-) with CTM. Four (3 MP and 1 ID-NAT, 0.5%) of the 778 NAT negative donations had low viral loads. Discussion: The decline in HCV-NAT yield cases raises the question of the relevance of NAT. Conversely, the increase in Ab+/NAT-donors, suggesting a growing number of resolved infections, argue for Ab discontinuation. In our experience, at least 0.5% of Ab+/NAT-donations had low RNA level when retested. Although the risk of viral transmission by such donations is probably low, the uncertainty associated with their infectivity goes against the removal of Ab in blood screening in our country.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu