Cryo-EM to visualize the structural organization of viruses.

Autor: de Oliveira GA; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil. Electronic address: gaugusto@bioqmed.ufrj.br., Silva JL; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
Jazyk: angličtina
Zdroj: Current opinion in virology [Curr Opin Virol] 2021 Aug; Vol. 49, pp. 86-91. Date of Electronic Publication: 2021 May 28.
DOI: 10.1016/j.coviro.2021.04.011
Abstrakt: It is intriguing to think that over millions of years, groups of nucleic acids got the chance to hold together with groups of proteins to build up what today is called a virus. Their only goal is to guarantee a successful replication inside a host. If their genome information is preserved, the task is accomplished. Viruses have evolved to infect organisms and propagate with high degree of adaptation, as it is the case of the SARS-CoV-2, agent of the 2020 world pandemic. The technological progress observed in the field of structural biology, especially in cryo-EM, has offered scientists the possibility of a better understanding of virus origins, behavior, and structural organization. In this minireview we summarize few perspectives about the origins and organization of viruses and the advances of cryo-EM to aid structural virologists to sample the virosphere.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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