Catalytic Asymmetric Synthesis of Benzobicyclo[3.2.1]octanes.

Autor: Anif Pasha M; Catalysis Laboratory, School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India., Peraka S; Catalysis Laboratory, School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India., Ramachary DB; Catalysis Laboratory, School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jul 21; Vol. 27 (41), pp. 10563-10568. Date of Electronic Publication: 2021 Jun 17.
DOI: 10.1002/chem.202100985
Abstrakt: Lawsone aldehydes were directly transformed into the biologically important, unique carbon skeleton of chiral methanobenzo[f]azulenes/methanodibenzo[a,d][7]annulenes in high dr and ee and in very good yields by using quinine-thiourea-catalyzed tandem Wittig/intramolecular Michael/intramolecular aldol reactions. This asymmetric catalytic tandem protocol will be highly useful because these final molecules are basic skeletons of important antibiotics.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje