Synthesis of Chitosan/Diatomite Composite as an Advanced Delivery System for Ibuprofen Drug; Equilibrium Studies and the Release Profile.

Autor:	Ibrahim SM; Materials Technologies and their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City 65211, Egypt.; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef City 65211, Egypt., Bin Jumah MN; Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia., Othman SI; Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia., Alruhaimi RS; Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia., Al-Khalawi N; Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia., Salama YF; Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City 65211, Egypt., Allam AA; Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef City 65211, Egypt., Abukhadra MR; Materials Technologies and their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City 65211, Egypt.; Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City 65211, Egypt.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2021 May 13; Vol. 6 (20), pp. 13406-13416. Date of Electronic Publication: 2021 May 13 (Print Publication: 2021).
DOI:	10.1021/acsomega.1c01514
Abstrakt:	Chitosan/diatomite nanocomposite (CS/D) was synthesized as a low-cost and highly porous structure of enhanced physicochemical properties to be applied as advanced carriers for ibuprofen drug (IB). The loading properties of CS/D were studied in comparison to diatomite as a separated phase and achieved a loading capacity of 562.6 mg/g. The loading reactions of IB into CS/D show pseudo-second-order kinetic behavior and Langmuir isotherm properties. This demonstrates homogeneous loading processes in monolayer forms and controlled essentially by physical mechanisms. This was confirmed by the calculated Gaussian energy (7.7 kJ/mol (D) and 7.9 kJ/mol (CS/D)) in addition to the thermodynamic parameters. The thermodynamic behavior for the IB loading process is related to spontaneous, favorable, and exothermic reactions. The CS/D composite is of promising IB release profile that extended to about 200 h with a maximum release of 91.5% at the gastric fluid (pH 1.2) and 97.3% in the intestinal fluid (pH 7.4). The IB release rate from CS/D can be controlled based on the ratio of the integrated chitosan in the composite. The IB release reactions from CS/D follow the assumption of Korsmeyer-Peppas kinetics with determined values for the diffusion exponent reflects complex diffusion and erosion as the affected mechanisms during the IB release process. Competing Interests: The authors declare no competing financial interest. (© 2021 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu