Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey.

Autor:	Karbuz A; Division of Pediatric Infectious Diseases, Okmeydani Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Akkoc G; Division of Pediatric Infectious Diseases, Istanbul Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Bedir Demirdag T; Department of Pediatric Infectious Diseases, Faculty of Medicine, Gazi University, Ankara, Turkey., Yilmaz Ciftdogan D; Department of Pediatric Infectious Diseases, Faculty of Medicine, Izmir Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey., Ozer A; Division of Pediatric Infectious Diseases, Van Training and Research Hospital, University of Health Sciences, Van, Turkey., Cakir D; Division of Pediatric Infectious Diseases, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Hancerli Torun S; Department of Pediatric Infectious Diseases, Faculty of Medicine, Istanbul University, Istanbul, Turkey., Kepenekli E; Division of Pediatric Infectious Diseases, Faculty of Medicine, Pendik Training and Research Hospital, Marmara University, Istanbul, Turkey., Erat T; Division of Pediatric Infectious Diseases, Sanliurfa Training and Research Hospital, Şanlıurfa, Turkey., Dalgic N; Division of Pediatric Infectious Diseases, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Ilbay S; Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Karaaslan A; Division of Pediatric Infectious Diseases, Kartal Dr. Lutfi Kırdar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Erdeniz EH; Division of Pediatric Infectious Diseases, Erzurum Training and Research Hospital, Erzurum, Turkey., Aygun FD; Division of Pediatric Infectious Diseases, Istanbul Kanuni Sultan Süleyman Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Bozdemir SE; Division of Pediatric Infectious Diseases, Dortcelik Children's Training and Research Hospital, Bursa, Turkey., Hatipoglu N; Division of Pediatric Infectious Diseases, Bakirkoy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Emiroglu M; Department of Pediatric Infectious Diseases, Faculty of Medicine, Selcuk University, Konya, Turkey., Sahbudak Bal Z; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ege University, Izmir, Turkey., Ciftci E; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Bayhan GI; Department of Pediatric Infectious Diseases, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey., Gayretli Aydin ZG; Department of Pediatric Infectious Diseases, Faculty of Medicine, Farabi Hospital, Karadeniz Technical University, Trabzon, Turkey., Ocal Demir S; Division of Pediatric Infectious Diseases, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey., Kilic O; Department of Pediatric Infectious Diseases, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey., Hacimustafaoglu M; Department of Pediatric Infectious Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey., Sener Okur D; Division of Pediatric Infectious Diseases, Denizli Hospital, Denizli, Turkey., Sen S; Department of Pediatric Infectious Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey., Yahsi A; Division of Pediatric Infectious Diseases, Samsun Training and Research Hospital, University of Health Sciences, Samsun, Turkey., Akturk H; Department of Pediatric Infectious Diseases, Faculty of Medicine, Koc University, Istanbul, Turkey., Cetin B; Department of Pediatric Infectious Diseases, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Sutcu M; Department of Pediatric Infectious Diseases, Faculty of Medicine, Istinye University, Istanbul, Turkey., Kara M; Division of Pediatric Infectious Diseases, Necip Fazil Training and Research Hospital, University of Health Sciences, Kahramanmaraş, Turkey., Uygun H; Department of Pediatric Infectious Diseases, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey., Tural Kara T; Department of Pediatric Infectious Diseases, Faculty of Medicine, Akdeniz University, Antalya, Turkey., Korukluoglu G; Public Health Institutions of Turkey, Director of Virology Department, Ankara, Turkey., Akgun O; Division of Pediatrics, Istanbul Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Üstündağ G; Division of Pediatric Infectious Diseases, Izmir Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey., Demir Mis M; Van Training and Research Hospital, University of Health Sciences, Van, Turkey., Sali E; Division of Pediatric Infectious Diseases, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Kaba O; Department of Pediatric Infectious Diseases, Faculty of Medicine, Istanbul University, Istanbul, Turkey., Yakut N; Division of Pediatric Infectious Diseases, Faculty of Medicine, Pendik Training and Research Hospital, Marmara University, Istanbul, Turkey., Kılıc O; Division of Pediatrics, Sanliurfa Training and Research Hospital, Şanlıurfa, Turkey., Kanik MK; Division of Pediatric Infectious Diseases, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Cetin C; Division of Pediatric Infectious Diseases, Kartal Dr. Lutfi Kırdar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Dursun A; Division of Pediatrics, Erzurum Training and Research Hospital, Erzurum, Turkey., Cicek M; Division of Pediatrics, Istanbul Kanuni Sultan Süleyman Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Kockuzu E; Division of Pediatrics, Dortcelik Children's Training and Research Hospital, Bursa, Turkey., Sevketoglu E; Division of Pediatric Intensive Care, Bakirkoy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Alkan G; Department of Pediatric Infectious Diseases, Faculty of Medicine, Selcuk University, Konya, Turkey., Guner Ozenen G; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ege University, Izmir, Turkey., İnce E; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Baydar Z; Department of Pediatrics, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey., Ozkaya AK; Department of Pediatric Emergency, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey., Ovali HF; Department of Pediatrics, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey., Tekeli S; Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey., Celebi S; Department of Pediatric Infectious Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey., Cubukcu B; Denizli Hospital, Denizli, Turkey., Bal A; Department of Pediatric Emergency, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey., Khalilova F; Department of Pediatrics, Faculty of Medicine, Koc University, Istanbul, Turkey., Kose M; Department of Pediatric Pulmonology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Hatipoglu HU; Department of Pediatrics, Faculty of Medicine, Istinye University, Istanbul, Turkey., Dalkiran T; Division of Pediatric Intensive Care, Necip Fazıl Training and Research Hospital, University of Health Sciences, Kahramanmaraş, Turkey., Turgut M; Department of Pediatric Infectious Diseases, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey., Basak Altas A; Public Health Institutions of Turkey, Director of Virology Department, Ankara, Turkey., Selcuk Duru HN; Division of Pediatrics, Istanbul Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Aksay A; Division of Pediatric Infectious Diseases, Izmir Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey., Saglam S; Van Training and Research Hospital, University of Health Sciences, Van, Turkey., Sari Yanartas M; Department of Pediatric Infectious Diseases, Faculty of Medicine, Istanbul University, Istanbul, Turkey., Ergenc Z; Division of Pediatric Infectious Diseases, Faculty of Medicine, Pendik Training and Research Hospital, Marmara University, Istanbul, Turkey., Akin Y; Division of Pediatrics, Kartal Dr. Lutfi Kırdar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Duzenli Kar Y; Division of Pediatrics, Erzurum Training and Research Hospital, Erzurum, Turkey., Sahin S; Division of Pediatrics, Dortcelik Children's Training and Research Hospital, Bursa, Turkey., Tuteroz SK; Department of Pediatric Infectious Diseases, Faculty of Medicine, Selcuk University, Konya, Turkey., Bilen NM; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ege University, Izmir, Turkey., Ozdemir H; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Senoglu MC; Department of Pediatrics, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey., Pariltan Kucukalioglu B; Department of Pediatrics, Kanuni Training and Research Hospital, University of Health Sciences, Trabzon, Turkey., Besli GE; Department of Pediatrics, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey., Kara Y; Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey., Turan C; Department of Pediatric Infectious Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey., Selbest Demirtas B; Denizli Hospital, Denizli, Turkey., Celikyurt A; Department of Pediatrics, Faculty of Medicine, Koc University, Istanbul, Turkey., Cosgun Y; Public Health Institutions of Turkey, Director of Virology Department, Ankara, Turkey., Elevli M; Division of Pediatrics, Istanbul Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Sahin A; Division of Pediatric Infectious Diseases, Izmir Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey., Bahtiyar Oguz S; Van Training and Research Hospital, University of Health Sciences, Van, Turkey., Somer A; Department of Pediatric Infectious Diseases, Faculty of Medicine, Istanbul University, Istanbul, Turkey., Karadag B; Division of Pediatric Pulmonology, Pendik Training and Research Hospital, Marmara University, Istanbul, Turkey., Demirhan R; Division of Thoracic Surgery, Kartal Dr. Lutfi Kırdar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Turk Dagi H; Department of Microbiology, Faculty of Medicine, Selcuk University, Konya, Turkey., Kurugol Z; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ege University, Izmir, Turkey., Taskin EC; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Sahiner A; Department of Pediatrics, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey., Yesil E; Department of Pediatric Infectious Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey., Ekemen Keles Y; Division of Pediatric Infectious Diseases, Izmir Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey., Sarikaya R; Van Training and Research Hospital, University of Health Sciences, Van, Turkey., Erdem Eralp E; Division of Pediatric Pulmonology, Pendik Training and Research Hospital, Marmara University, Istanbul, Turkey., Ozkinay F; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ege University, Izmir, Turkey., Konca HK; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Yilmaz S; Department of Pediatrics, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey., Gokdemir Y; Division of Pediatric Pulmonology, Pendik Training and Research Hospital, Marmara University, Istanbul, Turkey., Arga G; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Ozen S; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Coksuer F; Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey., Vatansever G; Department of Pediatric Emergency, Faculty of Medicine, Ankara University, Ankara, Turkey., Tezer H; Department of Pediatric Infectious Diseases, Faculty of Medicine, Gazi University, Ankara, Turkey., Kara A; Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2021 May 07; Vol. 9, pp. 631547. Date of Electronic Publication: 2021 May 07 (Print Publication: 2021).
DOI:	10.3389/fped.2021.631547
Abstrakt:	Objectives: The aim of this study is to identify the epidemiological, clinical, and laboratory features of coronavirus disease 2019 (COVID-19) in children. Methods: A retrospective study was conducted by pediatric infectious disease specialists from 32 different hospitals from all over Turkey by case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, and June 15, 2020 were included. Case characteristics including age, sex, dates of disease onset and diagnosis, family, and contact information were recorded. Clinical data, including the duration and severity of symptoms, were also collected. Laboratory parameters like biochemical tests and complete blood count, chest X-ray, and chest computed tomography (CT) were determined. Results: There were 1,156 confirmed pediatric COVID-19 cases. In total, male cases constituted 50.3% ( n = 582) and females constituted 49.7% ( n = 574). The median age of the confirmed cases was 10.75 years (4.5-14.6). Of the total cases, 90 were younger than 1 year of age (7.8%), 108 were 1-3 years of age (9.3%), 148 were 3-6 years of age (12.8%), 298 were 6-12 years of age (25.8%), 233 were 12-15 years of age (20.2%), and 268 cases were older than 15 years of age (23.2%). The most common symptom of the patients at the first visit was fever (50.4%) ( n = 583) for a median of 2 days (IQR: 1-3 days). Fever was median at 38.4°C (38.0-38.7°C). The second most common symptom was cough ( n = 543, 46.9%). The other common symptoms were sore throat ( n = 143, 12.4%), myalgia ( n = 141, 12.2%), dyspnea ( n = 118, 10.2%), diarrhea ( n = 112, 9.7%), stomachache ( n = 71, 6.1%), and nasal discharge ( n = 63, 5.4%). When patients were classified according to disease severity, 263 (22.7%) patients were asymptomatic, 668 (57.7%) patients had mild disease, 209 (18.1%) had moderate disease, and 16 (1.5%) cases had severe disease. One hundred and forty-nine (12.9%) cases had underlying diseases among the total cases; 56% of the patients who had severe disease had an underlying condition ( p < 0.01). The need for hospitalization did not differ between patients who had an underlying condition and those who do not have ( p = 0.38), but the need for intensive care was higher in patients who had an underlying condition ( p < 0.01). Forty-seven (31.5%) of the cases having underlying conditions had asthma or lung disease (38 of them had asthma). Conclusions: To the best of our knowledge, this is one of the largest pediatric data about confirmed COVID-19 cases. Children from all ages appear to be susceptible to COVID-19, and there is a significant difference in symptomatology and laboratory findings by means of age distribution. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Karbuz, Akkoc, Bedir Demirdag, Yilmaz Ciftdogan, Ozer, Cakir, Hancerli Torun, Kepenekli, Erat, Dalgic, Ilbay, Karaaslan, Erdeniz, Aygun, Bozdemir, Hatipoglu, Emiroglu, Sahbudak Bal, Ciftci, Bayhan, Gayretli Aydin, Ocal Demir, Kilic, Hacimustafaoglu, Sener Okur, Sen, Yahsi, Akturk, Cetin, Sutcu, Kara, Uygun, Tural Kara, Korukluoglu, Akgun, Üstündağ, Demir Mis, Sali, Kaba, Yakut, Kılıc, Kanik, Cetin, Dursun, Cicek, Kockuzu, Sevketoglu, Alkan, Guner Ozenen, İnce, Baydar, Ozkaya, Ovali, Tekeli, Celebi, Cubukcu, Bal, Khalilova, Kose, Hatipoglu, Dalkiran, Turgut, Basak Altas, Selcuk Duru, Aksay, Saglam, Sari Yanartas, Ergenc, Akin, Duzenli Kar, Sahin, Tuteroz, Bilen, Ozdemir, Senoglu, Pariltan Kucukalioglu, Besli, Kara, Turan, Selbest Demirtas, Celikyurt, Cosgun, Elevli, Sahin, Bahtiyar Oguz, Somer, Karadag, Demirhan, Turk Dagi, Kurugol, Taskin, Sahiner, Yesil, Ekemen Keles, Sarikaya, Erdem Eralp, Ozkinay, Konca, Yilmaz, Gokdemir, Arga, Ozen, Coksuer, Vatansever, Tezer and Kara.)
Databáze:	MEDLINE
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