A Multi-Center Retrospective Analysis Examining the Effect of Dipeptidyl Peptidase-4 Inhibitors on Progression-Free Survival in Patients With Prostate Cancer.

Autor:	Pan K; Internal Medicine, University of Florida, Gainesville, USA., Skelton WP; Oncology, Moffitt Cancer Center, Tampa, USA.; Internal Medicine, University of Florida, Gainesville, USA., Elzeneini M; Internal Medicine, University of Florida, Gainesville, USA., Nguyen TC; Internal Medicine, Moffitt Cancer Center, Tampa, USA., Franke AJ; Oncology, Moffitt Cancer Center, Tampa, USA., Ali A; Hematology and Oncology, University of Florida, Gainesville, USA., Bishnoi R; Hematology and Oncology, University of Florida, Gainesville, USA., Dang L; Oncology, Ochsner Health System, Baton Rouge, USA., Dang NH; Hematology and Oncology, University of Florida, Gainesville, USA., Kish J; Oncology, Moffitt Cancer Center, Tampa, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Apr 27; Vol. 13 (4), pp. e14712. Date of Electronic Publication: 2021 Apr 27.
DOI:	10.7759/cureus.14712
Abstrakt:	Background Cluster of differentiation 26/dipeptidyl peptidase-4 (DPP4) is a cell surface glycoprotein with multifaceted roles, including immune regulation, glucose metabolism, and tumorigenesis. Recent literature has identified DPP4 inhibitors to improve survival in diabetic patients with prostate cancer. DPP4 inhibitors have been proposed to play a role in prostate cancer, as DPP4 is found at higher levels in malignant prostate tissue compared to benign and correlates with PSA levels and cancer stage. In this multi-center retrospective study, we aim to define the effects of DPP4 inhibitors on progression-free survival (PFS) in diabetic patients with advanced-stage prostate cancer. Methodology We performed a retrospective analysis of 161 patients with diabetes and advanced-stage (III or IV) prostate cancer at the University of Florida Health Cancer Center and Moffitt Cancer Center. Our cohort included 120 patients on metformin (control group) and 41 on a DPP4 inhibitor (study group). Results No significant difference in progression of prostate cancer was identified between those on DPP4 inhibitors versus metformin (hazard ratio [HR]: 1.01; 95% confidence interval [CI]: 0.64-1.61; p = 0.955). Median time to progression was 3.5 years (range: 2.4-4.6 years). Conclusions Despite prior literature indicating survival benefit of DPP4 inhibitors in prostate cancer, our study did not identify a statistically significant improvement of PFS in diabetic patients with advanced prostate cancer. Additional analysis with larger sample sizes and prospective investigation with study of tumor microenvironment are needed to evaluate clinical impact and potential survival benefit of DPP4 inhibitors in prostate cancer. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Pan et al.)
Databáze:	MEDLINE
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