Etiology of Dementia in Thai Patients.
| Autor: | Dharmasaroja PA; Department of Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.; Faculty of Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand., Assanasen J; Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Pongpakdee S; Department of Medicine, Bhumibol Adulyadej Hospital, Royal Thai Airforce, Bangkok, Thailand., Jaisin K; Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Lolekha P; Department of Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand., Phanasathit M; Department of Psychiatry, Faculty of Medicine, Thammasat University, Pathumthani, Thailand., Cheewakriengkrai L; Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand., Chotipanich C; National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand., Witoonpanich P; Division of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Pitiyarn S; Medicine and Psychiatry Nursing Division, Department of Nursing, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Lertwilaiwittaya P; Division of Medical Genetics, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Dejthevaporn C; Division of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Limwongse C; Division of Medical Genetics, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Phanthumchinda K; Department of Medicine, Chulalongkorn University, Bangkok, Thailand. |
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| Jazyk: | angličtina |
| Zdroj: | Dementia and geriatric cognitive disorders extra [Dement Geriatr Cogn Dis Extra] 2021 Apr 15; Vol. 11 (1), pp. 64-70. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021). |
| DOI: | 10.1159/000515676 |
| Abstrakt: | Introduction: Molecular imaging has been developed and validated in Thai patients, comprising a portion of patients in the dementia registry. This should provide a more accurate diagnosis of the etiology of dementia, which was the focus of this study. Methods: This was a multicenter dementia study. The baseline characteristics, main presenting symptoms, and results of investigations and cognitive tests of the patients were electronically collected in the registry. Functional imaging and/or molecular imaging were performed in patients with an equivocal diagnosis of the causes of dementia, especially in atypical dementia or young onset dementia (YOD). Results: There were 454 patients in the study. The mean age of the patients was 78 years, with 60% female. Functional imaging and/or molecular imaging were performed in 57 patients (57/454 patients, 13%). The most common cause of dementia was Alzheimer's disease (AD; 50%), followed by vascular dementia (VAD; 24%), dementia with Lewy bodies (6%), Parkinson's disease dementia (6%), frontotemporal dementia (FTD; 2.6%), progressive supranuclear palsy (2%), multiple system atrophy (0.8%), and corticobasal syndrome (0.4%). YOD accounted for 17% (77/454 patients), with a mean age of 58 years. The causes of YOD were early onset amnestic AD (44%), VAD (16%), behavioral variant FTD (8%), posterior cortical atrophy (6.5%), and logopenic variant primary progressive aphasia (5.2%). Conclusion: AD was the most common cause of dementia in Thai patients and the distribution of other types of dementia and main presenting symptoms were similar to previous reports in Western patients; however, the proportion of YOD was higher. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2021 by S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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