Autoantibodies Against Ubiquitous and Confined Antigens in Patients With Ocular, Neuro-Ophthalmic and Congenital Cerebral Toxoplasmosis.
| Autor: | Goldberg-Murow M; Laboratorio de Inmunología Exprimental, Instituto Nacional de Pediatría, CDMX, Mexico.; Centro de Investigación de Ciencias de la Salud, Universidad Anáhuac, Huixquilucan, Mexico., Cedillo-Peláez C; Laboratorio de Inmunología Exprimental, Instituto Nacional de Pediatría, CDMX, Mexico., Concha-Del-Río LE; Clínica de Enfermedades Inflamatorias Oculares, Asociación Para Evitar la Ceguera en México, I.A.P., CDMX, Mexico., Cheja-Kalb R; Clínica de Enfermedades Inflamatorias Oculares, Asociación Para Evitar la Ceguera en México, I.A.P., CDMX, Mexico., Salgar-Henao MJ; Clínica de Enfermedades Inflamatorias Oculares, Asociación Para Evitar la Ceguera en México, I.A.P., CDMX, Mexico., Orozco-Velasco E; Clínica de Enfermedades Inflamatorias Oculares, Asociación Para Evitar la Ceguera en México, I.A.P., CDMX, Mexico., Luna-Pastén H; Laboratorio de Inmunología Exprimental, Instituto Nacional de Pediatría, CDMX, Mexico., Gómez-Chávez F; Laboratorio de Inmunología Exprimental, Instituto Nacional de Pediatría, CDMX, Mexico.; Cátedras CONACyT-Instituto Nacional de Pediatría, CDMX, Mexico.; Departamento de Formación Básica Disciplinaria, ENMyH-IPN, CDMX, Mexico., Ibarra A; Centro de Investigación de Ciencias de la Salud, Universidad Anáhuac, Huixquilucan, Mexico., Correa D; Laboratorio de Inmunología Exprimental, Instituto Nacional de Pediatría, CDMX, Mexico. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2021 May 12; Vol. 12, pp. 606963. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021). |
| DOI: | 10.3389/fimmu.2021.606963 |
| Abstrakt: | Toxoplasma gondii infection can trigger autoreactivity by different mechanisms. In the case of ocular toxoplasmosis, disruption of the blood-retinal barrier may cause exposure of confined retinal antigens such as recoverin. Besides, cross-reactivity can be induced by molecular mimicry of parasite antigens like HSP70, which shares 76% identity with the human ortholog. Autoreactivity can be a determining factor of clinical manifestations in the eye and in the central nervous system. We performed a prospective observational study to determine the presence of autoantibodies against recoverin and HSP70 by indirect ELISA in the serum of 65 patients with ocular, neuro-ophthalmic and congenital cerebral toxoplasmosis. We found systemic autoantibodies against recoverin and HSP70 in 33.8% and 15.6% of individuals, respectively. The presence of autoantibodies in cases of OT may be related to the severity of clinical manifestations, while in cases with CNS involvement they may have a protective role. Unexpectedly, anti-recoverin antibodies were found in patients with cerebral involvement, without ocular toxoplasmosis; therefore, we analyzed and proved cross-reactivity between recoverin and a brain antigen, hippocalcin, so the immunological phenomenon occurring in one immune-privileged organ (e.g. the central nervous system) could affect the environment of another (egg. the eye). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Goldberg-Murow, Cedillo-Peláez, Concha-del-Río, Cheja-Kalb, Salgar-Henao, Orozco-Velasco, Luna-Pastén, Gómez-Chávez, Ibarra and Correa.) |
| Databáze: | MEDLINE |
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