Long-term exposure to particulate matter from air pollution alters airway β-defensin-3 and -4 and cathelicidin host defense peptides production in a murine model.

Autor: Almaraz-De-Santiago J; Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato, Mexico., Solis-Torres N; Master's Program in Biological Sciences, Biological Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Quintana-Belmares R; Subdirección de Investigación Básic, Instituto Nacional de Cancerología, Mexico City, Mexico., Rodríguez-Carlos A; Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico., Rivas-Santiago B; Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico., Huerta-García J; Laboratory of Molecular and Environmental Biology, Biological Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Mercado-Reyes M; Laboratory of Conservation Biology, Biological Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Enciso-Moreno JA; Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico., Villagomez-Castro J; Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato, Mexico., González-Curiel I; Post-graduate Program in Sciences and Chemical Technology, Chemistry Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Osornio-Vargas Á; Department of Pediatrics, University of Alberta, ECHA, Edmonton, AB, Canada., Rivas-Santiago CE; CONACYT-Academic Unit of Chemical Sciences, University Autonomous of Zacatecas, Zacatecas, Mexico. Electronic address: cesarenriquer@yahoo.com.
Jazyk: angličtina
Zdroj: Peptides [Peptides] 2021 Aug; Vol. 142, pp. 170581. Date of Electronic Publication: 2021 May 28.
DOI: 10.1016/j.peptides.2021.170581
Abstrakt: Epidemiological studies have associated long-term exposure to environmental air pollution particulate matter (PM) with the development of diverse health problems. They include infectious respiratory diseases related to the deregulation of some innate immune response mechanisms, such as the host defense peptides' expression. Herein, we evaluated in BALB/c mice the effect of long-standing exposure (60 days) to urban-PM from the south of Mexico City, with aerodynamic diameters below 2.5 μm (PM 2.5 ) and 10 μm (PM 10 ) on the lung's gene expression and production of three host defense peptides (HDPs); murine beta-defensin-3, -4 (mBD-3, mBD-4) and cathelin-related antimicrobial peptide (CRAMP). We also evaluated mRNA levels of Il1b and Il10, two cytokines related to the expression of host defense peptides. Exposure to PM 2.5 and PM 10 differentially induced lung inflammation, being PM 2.5 , which caused higher inflammation levels, probably associated with a differential deposition on the airways, that facilitate the interaction with alveolar macrophages. Inflammation levels were associated with an early upregulation of the three HDPs assessed and an increment in Il1b mRNA levels. Interestingly, after 28 days of exposure, Il10 mRNA upregulation was observed and was associated with the downregulation of HDPs and Il1b mRNA levels. The upregulation of Il10 mRNA and suppression of HDPs might facilitate microbial colonization and the development of diseases associated with long-term exposure to PM.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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