Long-term exposure to particulate matter from air pollution alters airway β-defensin-3 and -4 and cathelicidin host defense peptides production in a murine model.
Autor: | Almaraz-De-Santiago J; Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato, Mexico., Solis-Torres N; Master's Program in Biological Sciences, Biological Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Quintana-Belmares R; Subdirección de Investigación Básic, Instituto Nacional de Cancerología, Mexico City, Mexico., Rodríguez-Carlos A; Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico., Rivas-Santiago B; Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico., Huerta-García J; Laboratory of Molecular and Environmental Biology, Biological Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Mercado-Reyes M; Laboratory of Conservation Biology, Biological Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Enciso-Moreno JA; Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico., Villagomez-Castro J; Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato, Mexico., González-Curiel I; Post-graduate Program in Sciences and Chemical Technology, Chemistry Sciences School, University Autonomous of Zacatecas, Zacatecas, Mexico., Osornio-Vargas Á; Department of Pediatrics, University of Alberta, ECHA, Edmonton, AB, Canada., Rivas-Santiago CE; CONACYT-Academic Unit of Chemical Sciences, University Autonomous of Zacatecas, Zacatecas, Mexico. Electronic address: cesarenriquer@yahoo.com. |
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Jazyk: | angličtina |
Zdroj: | Peptides [Peptides] 2021 Aug; Vol. 142, pp. 170581. Date of Electronic Publication: 2021 May 28. |
DOI: | 10.1016/j.peptides.2021.170581 |
Abstrakt: | Epidemiological studies have associated long-term exposure to environmental air pollution particulate matter (PM) with the development of diverse health problems. They include infectious respiratory diseases related to the deregulation of some innate immune response mechanisms, such as the host defense peptides' expression. Herein, we evaluated in BALB/c mice the effect of long-standing exposure (60 days) to urban-PM from the south of Mexico City, with aerodynamic diameters below 2.5 μm (PM (Copyright © 2021 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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