Effects of chemotherapy on operant responding for palatable food in male and female mice.

Autor:	Meade JA; Department of Pharmacology and Toxicology., Fowlkes AN; Department of Pharmacology and Toxicology., Wood MJ; Department of Pharmacology and Toxicology., Kurtz MC; Department of Pharmacology and Toxicology., May MM; Department of Pharmacology and Toxicology., Toma WB; Department of Pharmacology and Toxicology., Warncke UO; Department of Pharmacology and Toxicology.; Center for Clinical and Translational Research, School of Medicine., Mann J; Department of Pharmacology and Toxicology., Mustafa M; Department of Pharmacology and Toxicology., Lichtman AH; Department of Pharmacology and Toxicology.; Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, Virginia, USA., Damaj MI; Department of Pharmacology and Toxicology.; Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, Virginia, USA.
Jazyk:	angličtina
Zdroj:	Behavioural pharmacology [Behav Pharmacol] 2021 Aug 01; Vol. 32 (5), pp. 422-434.
DOI:	10.1097/FBP.0000000000000635
Abstrakt:	Patients treated with cancer chemotherapeutics frequently report chemotherapy-induced peripheral neuropathy (CIPN), changes in mood (depression and anxiety) and functional impairments. Rodent models of CIPN elicit limited alterations in functional behaviors, which pose challenges in developing preclinical models of chemotherapy-induced behavioral depression. The study examined the consequences of chemotherapy-induced mechanical hypersensitivity (paclitaxel: 32 or 64 mg/kg, cumulative; oxaliplatin: 30 mg/kg, cumulative) on behavioral depression, as measured with operant responding for palatable food during periods of food restriction and ad libitum chow, consumption of noncontingently available palatable food in the presence of ad libitum chow, and voluntary wheel running. The study employed two inbred mouse strains (C57BL/6J and Balb/cJ) and examined potential sex differences. All chemotherapeutic regimens caused profound mechanical hypersensitivity for the duration of the observation periods (up to 7 months), but no treatments changed voluntary wheel running or consumption of noncontingent palatable food. The high dose of paclitaxel temporarily reduced operant responding for palatable food in male C57BL/6J mice undergoing food restriction or maintained on ad libitum chow. However, paclitaxel failed to decrease operant responding for palatable food in free-feeding female C57BL/6J mice or Balb/cJ mice of either sex. Moreover, oxaliplatin did not significantly alter operant responding for palatable food in male or female C57BL/6J mice maintained on ad libitum chow. These findings demonstrate a dissociation between chemotherapy-induced mechanical hypersensitivity and behavioral depression. The transient effects of paclitaxel on operant responding in male C57BL/6J mice may represent a fleeting behavioral correlate of chemotherapy-associated pain-like behaviors. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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