Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis.

Autor: Mäkinen A; Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland; Fimlab Laboratories, Department of Pathology, Tampere University Hospital, Tampere, Finland. Electronic address: artturi.makinen@tuni.fi., Nikkilä A; Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland., Mehtonen J; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Teppo S; Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland., Oksa L; Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland., Nordlund J; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Rounioja S; Fimlab Laboratories, Department of Hematology, Tampere University Hospital, Tampere, Finland., Pohjolainen V; Fimlab Laboratories, Department of Pathology, Tampere University Hospital, Tampere, Finland., Laukkanen S; Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland., Heinäniemi M; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Paavonen T; Fimlab Laboratories, Department of Pathology, Tampere University Hospital, Tampere, Finland; Department of Pathology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Lohi O; Faculty of Medicine and Health Technology, Tampere Center for Child Health Research, Tampere University, Tampere, Finland; Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.
Jazyk: angličtina
Zdroj: Pathology [Pathology] 2021 Dec; Vol. 53 (7), pp. 875-882. Date of Electronic Publication: 2021 May 26.
DOI: 10.1016/j.pathol.2021.02.013
Abstrakt: B-cell lineage acute lymphoblastic leukaemia (B-ALL) is the most common paediatric malignancy. Transcription factor B-cell lymphoma 6 (BCL6) is essential to germinal centre formation and antibody affinity maturation and plays a major role in mature B-cell malignancies. More recently, it was shown to act as a critical downstream regulator in pre-BCR+ B-ALL. We investigated the expression of the BCL6 protein in a population-based cohort of paediatric B-ALL cases and detected moderate to strong positivity through immunohistochemistry in 7% of cases (8/117); however, only two of eight BCL6 cases (25%) co-expressed the ZAP70 protein. In light of these data, the subtype with active pre-BCR signalling constitutes a rare entity in paediatric B-ALL. In three independent larger cohorts with gene expression data, high BCL6 mRNA levels were associated with the TCF3-PBX1, Ph-like, NUTM1, MEF2D and PAX5-alt subgroups and the 'metagene' signature for pre-BCR-associated genes. However, higher-than-median BCL6 mRNA level alone was associated with favourable event free survival in the Nordic paediatric cohort, indicating that using BCL6 as a diagnostic marker requires careful design, and evaluation of protein level is needed alongside the genetic or transcriptomic data.
(Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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