Unfractionated heparin reduces hepcidin levels in critically ill patients.

Autor: Vagionas D; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Politou M; Haematology Laboratory-Blood Bank, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece., Kompoti M; Intensive Care Unit, General Hospital of Eleusis Thriasio, Athens, Greece., Papadakis DD; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Kostakou E; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Theodoulou D; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Kaniaris E; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Rovina N; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Koutsoukou A; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece., Vasileiadis I; Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece.
Jazyk: angličtina
Zdroj: Internal medicine journal [Intern Med J] 2021 May; Vol. 51 (5), pp. 797-801.
DOI: 10.1111/imj.15317
Abstrakt: A strong anti-hepcidin activity has been observed in heparins. Mean hepcidin levels were significantly reduced compared to baseline, following the first day of unfractionated heparin administration in critically patients. Heparin displayed a strong independent negative association with hepcidin. These results may lead to future treatment methods of forms of anaemia characterised by hepcidin excess, common among the critically ill.
(© 2021 Royal Australasian College of Physicians.)
Databáze: MEDLINE
Externí odkaz: