Delayed Behavioral and Neurochemical Effects of Anti-Glutamate Antibodies in Aging C57BL/6 Mice.

Autor: Davydova TV; Research Institute of General Pathology and Pathophysiology, Moscow, Russia. dav-ta@yandex.ru., Gruden MA; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia., Kudrin VS; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Narkevich VB; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Vetrile LA; Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Zakharova IA; Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Sewell RDE; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 May; Vol. 171 (1), pp. 19-22. Date of Electronic Publication: 2021 May 28.
DOI: 10.1007/s10517-021-05163-x
Abstrakt: We analyzed delayed effect of intranasal administration of anti-glutamate antibodies on mnestic function and tissue concentrations of neurotransmitters in the hippocampus and prefrontal cortex in aging C57BL/6 mice. It was found that after 14-day administration of anti-glutamate antibodies, improvement of the passive avoidance conditioning persisted for 7 days after the treatment was discontinued. In 7 days after discontinuation of treatment, increased content of dopamine and its metabolites as well as aspartic acid and taurine was observed in the hippocampus of mice treated with anti-glutamate antibodies. In the prefrontal cortex, administration of anti-glutamate antibodies had no effect on the levels of neurotransmitters, but increased the concentration of glutamate.
Databáze: MEDLINE
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