Potential Role of the Galectin-9/TIM-3 Axis in the Disparate Progression of SARS-CoV-2 in a Married Couple: A Case Report.

Autor:	Martín-Quirós A; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Madrid, Spain., Maroun-Eid C; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain., Avendaño-Ortiz J; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., Lozano-Rodríguez R; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., Valentín Quiroga J; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., Terrón V; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., Montalbán-Hernández K; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., García-Garrido MA; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Madrid, Spain., Muñoz Del Val E; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Madrid, Spain., Del Balzo-Castillo Á; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., Rubio C; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., Cubillos-Zapata C; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain., Aguirre LA; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain., López-Collazo E; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Madrid, Spain.; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Biomedicine hub [Biomed Hub] 2021 Apr 19; Vol. 6 (1), pp. 48-58. Date of Electronic Publication: 2021 Apr 19 (Print Publication: 2021).
DOI:	10.1159/000514727
Abstrakt:	We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and immune cell distribution in blood from admission to exitus in patient 1 and from admission to discharge and recovery in patient 2. A detailed clinical follow-up accompanied by a longitudinal analysis of immune phenotypes and IC levels is shown. The continuous increase in the soluble IC ligand galectin-9 (Gal-9) and the increment in T-cell immunoglobulin and mucin domain-containing 3 (TIM-3) protein in T cells in patient 1 suggests an activation of the Gal-9/TIM-3 axis and, subsequently, a potential cell exhaustion in this patient that did not occur in patient 2. Our data indicate that the Gal-9/TIM-3 axis could be a potential target in this clinical setting, along with a patent effector memory T-cell reduction. Competing Interests: All authors declare no conflicts of interest. (Copyright © 2021 by S. Karger AG, Basel.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu