| Autor: |
Morell-Garcia D; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain. dr.morell.uab@gmail.com.; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain. dr.morell.uab@gmail.com., Ramos-Chavarino D; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain., Bauça JM; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain.; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain., Argente Del Castillo P; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain., Ballesteros-Vizoso MA; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain., García de Guadiana-Romualdo L; Laboratory Medicine Department, Hospital Universitario Santa Lucía, Cartagena, Spain., Gómez-Cobo C; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain.; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain., Pou JA; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain.; Internal Medicine Department, Hospital Universitari Son Espases, Palma de Mallorca, Spain., Amezaga-Menéndez R; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain.; Intensive Care Unit, Hospital Universitari Son Espases, Palma de Mallorca, Spain., Alonso-Fernández A; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain.; Respiratory Medicine Department, Hospital Universitari Son Espases, Palma de Mallorca, Spain., Llompart I; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain.; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain., García-Raja A; Laboratory Medicine Department, Hospital Universitari Son Espases, Ctra. Valldemossa 79, mòdul 0-J., 07120, Palma de Mallorca, Spain.; Institut d'Investigació Sanitària de Les Illes Balears (IdISBa), Palma de Mallorca, Spain. |
| Abstrakt: |
Risk factors associated with severity and mortality attributable to COVID-19 have been reported in different cohorts, highlighting the occurrence of acute kidney injury (AKI) in 25% of them. Among other, SARS-CoV-2 targets renal tubular cells and can cause acute renal damage. The aim of the present study was to evaluate the usefulness of urinary parameters in predicting intensive care unit (ICU) admission, mortality and development of AKI in hospitalized patients with COVID-19. Retrospective observational study, in a tertiary care hospital, between March 1st and April 19th, 2020. We recruited adult patients admitted consecutively and positive for SARS-CoV-2. Urinary and serum biomarkers were correlated with clinical outcomes (AKI, ICU admission, hospital discharge and in-hospital mortality) and evaluated using a logistic regression model and ROC curves. A total of 199 COVID-19 hospitalized patients were included. In AKI, the logistic regression model with a highest area under the curve (AUC) was reached by the combination of urine blood and previous chronic kidney disease, with an AUC of 0.676 (95%CI 0.512-0.840; p = 0.023); urine specific weight, sodium and albumin in serum, with an AUC of 0.837 (95% CI 0.766-0.909; p < 0.001) for ICU admission; and age, urine blood and lactate dehydrogenase levels in serum, with an AUC of 0.923 (95%CI 0.866-0.979; p < 0.001) for mortality prediction. For hospitalized patients with COVID-19, renal involvement and early alterations of urinary and serum parameters are useful as prognostic factors of AKI, the need for ICU admission and death. |
