[Acute kidney injury and severe malaria in adults: A monocentric descriptive study in Madagascar using KDIGO criteria].

Autor: Randrianarisoa RMF; Service de médecine interne, centre hospitalier Joseph Raseta Befelatanana, Andrefan'Ambohijanahary, Antananarivo, Madagascar. Electronic address: rrmf7763@gmail.com., Ranivoharisoa EM; Service de néphrologie, centre hospitalier Joseph Raseta Befelatanana, Antananarivo, Madagascar., Ahmed M; Service de médecine interne, centre hospitalier Joseph Raseta Befelatanana, Andrefan'Ambohijanahary, Antananarivo, Madagascar., Ramilitiana B; Service de néphrologie, centre hospitalier Joseph Raseta Befelatanana, Antananarivo, Madagascar., Rakotomalala NL; Service de néphrologie, centre hospitalier Joseph Raseta Befelatanana, Antananarivo, Madagascar., Randria MJD; Service des maladies infectieuses, centre hospitalier Joseph Raseta Befelatanana, Antananarivo, Madagascar., Randriamarotia WFH; Service de néphrologie, centre hospitalier Joseph Raseta Befelatanana, Antananarivo, Madagascar.
Jazyk: francouzština
Zdroj: Nephrologie & therapeutique [Nephrol Ther] 2021 Oct; Vol. 17 (6), pp. 434-440. Date of Electronic Publication: 2021 May 25.
DOI: 10.1016/j.nephro.2021.03.003
Abstrakt: Introduction: Acute Kidney Injury (AKI) is one of the criteria for severe malaria with a varied incidence. Our objectives are to determine the prevalence of malaria-associated AKI and to report the characteristics of patients with the evolution of cases.
Patients and Method: This is a 5-year retrospective descriptive study from January 1, 2015 to December 31, 2019 in the Infectious Diseases department of the University Hospital Center of Befelatanana Antananarivo. Among 379 patients diagnosed, 103 patients (27,18%) with associated AKI were included. We used the criteria of Kidney Disease Improving Global Outcomes group to define AKI.
Results: The prevalence of AKI was 27.18%. The mean age of patients was 34.92 years and the sex-ratio was 3.68. Plasmodium falciparum was the causative agent in 98.06% of cases followed by Plasmodium vivax. Diuresis was preserved in 69.86% of cases. Jaundice was the main sign of severity associated (49.51%). The mean creatinine level was 466.93μmol/L. The evolution was favorable under antimalarial drug and rehydration. Dialysis was required in 25.24% of cases. Thirteen patients had died, a rate of 12.62%, of which 8 patients (61.54%) had dialysis criteria but had not been purged for economic reasons.
Conclusion: AKI is a frequent complication of malaria. It is responsible for significant mortality despite improved care in the fight against malaria.
(Copyright © 2021 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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